R-Elvitegravir

Base Information

Chemical Name:R-Elvitegravir
CAS No.:1177256-05-1
Molecular Formula:C23H23ClFNO5
Molecular Weight:447.8838232
Hs Code.:

Synonyms:R-Elvitegravir;6-[(3-Chloro-2-fluorophenyl)methyl]-1,4-dihydro-1-[(1R)-1-(hydroxymethyl)-2-methylpropyl]-7-methoxy-4-oxo-3-quinolinecarboxylic acid

Suppliers and Price of R-Elvitegravir

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of R-Elvitegravir

Chemical Property:

Melting Point:150-151℃

Purity/Quality:: 98%,99%, ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of R-Elvitegravir

There total 12 articles about R-Elvitegravir which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.9%

: (R)-methyl 6-(3-chloro-2-fluorobenzyl)-1,4-dihydro-1-(1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxoquinoline-3-carboxylate

: 1177256-05-1,697761-98-1
6-(3-chloro-2-fluorobenzyl)-1-((2R)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: With sodium hydroxide; In methanol; water; at 20 ℃; for 5h;
DOI:10.1002/jhet.2477

Reference yield: 17.0%

: 1177256-05-1,697761-98-1
6-(3-chloro-2-fluorobenzyl)-1-((2R)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: With hydrogenchloride; water; In tetrahydrofuran; at 20 ℃; for 4h;

With water; sodium hydroxide; In methanol; at 20 ℃;

Reference yield:

: 1177256-74-4
1-((2R)-1-tert-butyldimethylsilyloxy-3-methylbutan-2-yl)-6-(3-chloro-2-fluorobenzyl)-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester

: 124-41-4
sodium methylate

: 1177256-05-1,697761-98-1
6-(3-chloro-2-fluorobenzyl)-1-((2R)-1-hydroxy-3-methylbutan-2-yl)-7-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Guidance literature:: 1-((2R)-1-tert-butyldimethylsilyloxy-3-methylbutan-2-yl)-6-(3-chloro-2-fluorobenzyl)-7-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid ethyl ester; sodium methylate; With methanol; for 3h; Reflux;

With acetic acid;
DOI:10.1021/jm900460z