cis-Hydroxy Praziquantel

Base Information

Chemical Name:cis-Hydroxy Praziquantel
CAS No.:134924-68-8
Molecular Formula:C19H24N2O3
Molecular Weight:328.40546
Hs Code.:
Mol file:134924-68-8.mol

Synonyms:cis-Hydroxy Praziquantel;1,2,3,6,7,11b-Hexahydro-2-[(cis-4-hydroxycyclohexyl)carbonyl]-4H-pyrazino[2,1-a]isoquinolin-4-one;cis-(+/-)-1,2,3,6,7,11b-Hexahydro-2-[(4-hydroxycyclohexyl)carbonyl]- 4H-pyrazino[2,1-a]isoquinolin-4-one

Suppliers and Price of cis-Hydroxy Praziquantel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
cis-HydroxyPraziquantel
25mg
$ 580.00

Total 2 raw suppliers

Chemical Property of cis-Hydroxy Praziquantel

Chemical Property:

Vapor Pressure:7.9E-15mmHg at 25°C
Boiling Point:591.3°C at 760 mmHg
Flash Point:311.4°C
PSA：60.85000
Density:1.3g/cm³
LogP:1.38150
Storage Temp.:Refrigerator
Solubility.:Chloroform (Slightly), Ethanol (Slightly, Sonicated), Ethyl Acetate (Slightly),

Purity/Quality:

97% ^*data from raw suppliers

cis-HydroxyPraziquantel ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses The main cis-monohydroxylated metabolite of Praziquantel (P702095).

Technology Process of cis-Hydroxy Praziquantel

There total 6 articles about cis-Hydroxy Praziquantel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 57452-32-1,134924-66-6,134924-67-7
2-(4-oxocyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

: 134924-68-8
2-(4-cis-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

Guidance literature:: With potassium tri-sec-butyl-borohydride; In tetrahydrofuran; at -70 ℃; for 3h;
DOI:10.1002/ardp.19913240409

Reference yield:

: 57452-32-1,134924-66-6,134924-67-7
2-(4-oxocyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

: 134924-71-3
2-(4-trans-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

: 134924-68-8
2-(4-cis-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

Guidance literature:: With sodium tetrahydroborate; In methanol; at 0 ℃; for 20h; Yield given. Yields of byproduct given;
DOI:10.1002/ardp.19913240409

Reference yield:

: 874-61-3
4-oxocyclohexanecarboxylic acid

: 134924-68-8
2-(4-cis-hydroxycyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino<2,1-a>isoquinolin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: SOCl₂ / dimethylformamide; CH₂Cl₂ / 0.5 h / -40 °C

2: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: NaBH₄ / methanol / 20 h / 0 °C

With sodium tetrahydroborate; thionyl chloride; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ardp.19913240409