134924-71-3 Usage
Uses
Used in Pharmaceutical Industry:
Trans-Hydroxy Praziquantel is used as an active pharmaceutical ingredient for the development of new drugs targeting parasitic infections. Its hydroxy group enables it to interact with specific biological targets, potentially enhancing the efficacy of antiparasitic treatments.
Used in Research and Development:
In the field of pharmaceutical research and development, Trans-Hydroxy Praziquantel serves as a valuable compound for studying the mechanisms of action and potential applications of Praziquantel and its metabolites. This can lead to the discovery of new therapeutic approaches and the development of more effective antiparasitic drugs.
Used in Drug Delivery Systems:
Similar to Gallotannin, Trans-Hydroxy Praziquantel can be incorporated into novel drug delivery systems to improve its bioavailability, delivery, and therapeutic outcomes. By employing various organic and metallic nanoparticles as carriers, the limitations of Trans-Hydroxy Praziquantel can be overcome, enhancing its overall effectiveness in treating parasitic infections.
Check Digit Verification of cas no
The CAS Registry Mumber 134924-71-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,4,9,2 and 4 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 134924-71:
(8*1)+(7*3)+(6*4)+(5*9)+(4*2)+(3*4)+(2*7)+(1*1)=133
133 % 10 = 3
So 134924-71-3 is a valid CAS Registry Number.
InChI:InChI=1/C19H24N2O3/c22-15-7-5-14(6-8-15)19(24)20-11-17-16-4-2-1-3-13(16)9-10-21(17)18(23)12-20/h1-4,14-15,17,22H,5-12H2
134924-71-3Relevant academic research and scientific papers
Microsomal oxidation of praziquantel
Hogemann,Kiec-Kononowicz,Westhoff,Blaschke
, p. 1159 - 1162 (2007/10/02)
The metabolism of the non-labelled and 14C-labelled anthelmintic drug, praziquantel (PZQ; CAS 55268-74-1) was investigated by means of microsomal oxidation with rat liver homogenates. The metabolites formed were determined with linear thin-layer chromatography (TLC) radioactivity scanner after TLC separation, separated with TLC and analysed with high-pressure liquid chromatography and mass spectrometry method. The amounts and properties of the formed metabolites were described. It was stated that after microsomal oxidation monohydroxylated PZQ derivatives were obtained in greatest amount; the main fraction formed (35%) contained 4-OH-PZQ derivate which consisted of 80% cis-4-OH-PZQ and 20% of trans-4-OH-PZQ.
