3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide
CAS No.:1403332-38-6
Molecular Formula:C₁₅H₁₃ClN₆O
Molecular Weight:328.761
Hs Code.:
Mol file:1403332-38-6.mol

Synonyms:3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide

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Chemical Property of 3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide

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Technology Process of 3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide

There total 5 articles about 3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1403333-46-9
3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid

: 1403332-38-6
3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: With ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; at 0 - 20 ℃; for 3h;

Reference yield:

: 1403333-39-0
ethyl 1-(5-chloro-2-methylphenyl)-3-[(2E)-3-(dimethylamino)prop-2-enoyl]-1H-pyrazole-5-carboxylate

: 1403332-38-6
3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide / 110 °C

1.2: 1 h

1.3: 5 °C

2.1: N,N-dimethyl-formamide; N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ammonium chloride / 3 h / 0 - 20 °C

With ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide;

Reference yield:

: 148839-33-2
(5-chloro-2-methylphenyl)boronic acid

: 1403332-38-6
3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 3 h / 90 °C

3.1: N,N-dimethyl-formamide / 110 °C

3.2: 1 h

3.3: 5 °C

4.1: N,N-dimethyl-formamide; N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; ammonium chloride / 3 h / 0 - 20 °C

With pyridine; copper diacetate; ammonium chloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; In dichloromethane;