3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid

Base Information

Chemical Name:3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid
CAS No.:1403333-46-9
Molecular Formula:C₁₅H₁₂ClN₅O₂
Molecular Weight:329.746
Hs Code.:
Mol file:1403333-46-9.mol

Synonyms:3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid

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Chemical Property of 3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid

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Technology Process of 3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid

There total 5 articles about 3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 90332-86-8,3425-08-9
guanidinium carbonate

: 1403333-39-0
ethyl 1-(5-chloro-2-methylphenyl)-3-[(2E)-3-(dimethylamino)prop-2-enoyl]-1H-pyrazole-5-carboxylate

: 1403333-46-9
3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: guanidinium carbonate; ethyl 1-(5-chloro-2-methylphenyl)-3-[(2E)-3-(dimethylamino)prop-2-enoyl]-1H-pyrazole-5-carboxylate; With N,N-dimethyl-formamide; at 110 ℃;

With methanol; sodium hydroxide; In tetrahydrofuran; for 1h;

With citric acid; In water; at 5 ℃;

Reference yield: 65.0%

: 1403333-39-0
ethyl 1-(5-chloro-2-methylphenyl)-3-[(2E)-3-(dimethylamino)prop-2-enoyl]-1H-pyrazole-5-carboxylate

: 124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9
guanidine hydrogen carbonate

: 1403333-46-9
3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: ethyl 1-(5-chloro-2-methylphenyl)-3-[(2E)-3-(dimethylamino)prop-2-enoyl]-1H-pyrazole-5-carboxylate; guanidine hydrogen carbonate; In N,N-dimethyl-formamide; at 110 ℃;

With methanol; sodium hydroxide; In tetrahydrofuran; for 1h;

Reference yield:

: 148839-33-2
(5-chloro-2-methylphenyl)boronic acid

: 1403333-46-9
3-(2-aminopyrimidin-4-yl)-1-(5-chloro-2-methylphenyl)-1H-pyrazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine; copper diacetate / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.1: N,N-dimethyl-formamide / 3 h / 90 °C

3.1: N,N-dimethyl-formamide / 110 °C

3.2: 1 h

3.3: 5 °C

With pyridine; copper diacetate; N,N-dimethyl-formamide; In dichloromethane;