Lorediplon

Base Information

Chemical Name:Lorediplon
CAS No.:917393-39-6
Molecular Formula:C₂₀H₁₅FN₄O₂S
Molecular Weight:394.429
Hs Code.:
UNII:VKU6Z23NSY
ChEMBL ID:CHEMBL4303403
DSSTox Substance ID:DTXSID00238684
NCI Thesaurus Code:C170129
Wikidata:Q6680290
Wikipedia:Lorediplon
Mol file:917393-39-6.mol

Synonyms:lorediplon

Suppliers and Price of Lorediplon

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Lorediplon >98%
100 mg
$ 300.00

DC Chemicals
Lorediplon >98%
1 g
$ 1500.00

DC Chemicals
Lorediplon >98%
250 mg
$ 600.00

Crysdot
Lorediplon 98+%
100mg
$ 534.00

Crysdot
Lorediplon 98+%
50mg
$ 329.00

ChemScene
Lorediplon 99.78%
10mg
$ 50.00

ChemScene
Lorediplon 99.78%
50mg
$ 200.00

Chemenu
N-(2-fluoro-5-(3-(thiophene-2-carbonyl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-N-methylacetamide 98%
100mg
$ 359.00

Cayman Chemical
Lorediplon ≥98%
25mg
$ 123.00

Cayman Chemical
Lorediplon ≥98%
10mg
$ 53.00

Total 36 raw suppliers

Chemical Property of Lorediplon

Chemical Property:

PSA：95.81000
LogP:3.81060
XLogP3:2.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:394.08997507
Heavy Atom Count:28
Complexity:609

Purity/Quality:

99%, ^*data from raw suppliers

Lorediplon >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)N(C)C1=C(C=CC(=C1)C2=CC=NC3=C(C=NN23)C(=O)C4=CC=CS4)F
Recent EU Clinical Trials:Double-blind, randomized, placebo-controlled cross-over dose finding study of two doses of lorediplon in adult patients with insomnia disorder
Description Lorediplon is a non-benzodiazepine belonging to pyrazolopyrimidine family isunderdevelopment for the management for insomnia. Lorediplon acts by modulationof the GABAgreceptor. Its long plasma half-life has the potential of hypnotic effect. Ithas the potential for maintenance of sleep and the sleep architecture. In the phase Ipharmacodynamic study,it showed better efficacy in quality and maintenance ofsleep as compared with zolpidem. It has been shown to be well tolerated, safe with noresidual effects as compared with other sedative-hypnotic. Currently, the drug has completed Phase ll clinical trial. Results indicated strongefficacy in sleep maintenance with an acceptable safety profile. It also seems topreserve natural sleep architecture.
Uses Lorediplon is GABAA receptor modulator and is used in the treatment of insomnia.

Technology Process of Lorediplon

There total 2 articles about Lorediplon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

: 917393-46-5
N-[5-(3-dimethylamino-acryloyl)-2-fluoro-phenyl]-N-methyl-acetamide

: 96219-87-3
(5-amino-1H-pyrazol-4-yl)-thiophen-2-yl-methanone

: 917393-39-6
Lorediplon

Guidance literature:: With acetic acid; at 75 ℃; for 4h;

Reference yield:

: 552301-41-4
N-(5-acetyl-2-fluorophenyl)-N-acetamide

: 917393-39-6
Lorediplon

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / acetonitrile / 15 h / 15 - 30 °C

2: 8 h / Reflux

3: acetic acid / 4 h / 75 °C

With acetic acid; sodium hydroxide; In acetonitrile;