1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)-propyl)-

Base Information

Chemical Name:1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)-propyl)-
CAS No.:124556-77-0
Molecular Formula:C22H22Cl2N6O
Molecular Weight:457.3557
Hs Code.:
DSSTox Substance ID:DTXSID20154433
Wikidata:Q83021675

Synonyms:1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)-propyl)-;124556-77-0;C22H22Cl2N6O;DTXSID20154433;C22-H22-Cl2-N6-O;LS-156620

Suppliers and Price of 1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)-propyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)-propyl)-

Chemical Property:

Vapor Pressure:2.18E-15mmHg at 25°C
Boiling Point:621.9°Cat760mmHg
Flash Point:329.9°C
Density:1.46g/cm³
XLogP3:4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:5
Exact Mass:456.1232147
Heavy Atom Count:31
Complexity:725

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1CCCN2C(=O)N3C(=N2)C4=C(C=C(C=C4)Cl)C=N3)C5=CC(=CC=C5)Cl

Technology Process of 1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)-propyl)-

There total 4 articles about 1,2,4-Triazolo(3,4-a)phthalazin-3(2H)-one, 8-chloro-2-(3-(4-(3-chlorophenyl)-1-piperazinyl)-propyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 39577-43-0
1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine

: 124556-79-2
8-chloro-1,2,4-triazolo<3,4-a>phthalazin-3(2H)-one

: 124556-77-0
8-Chloro-2-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-one

Guidance literature:: With sodium hydride; mineral oil; In N,N-dimethyl-formamide; at 80 ℃; for 25h; 1.) 60 deg C, 2 h;

Reference yield:

: 57835-96-8
6-chlorophthalazine-1(2H)-one

: 124556-77-0
8-Chloro-2-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-one

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / phosphorus oxychloride / 0.33 h / 100 °C

2: 91 percent / hydrazine hydrate / ethanol / 1 h / Heating

3: 80 percent / 1 h / 330 - 350 °C

4: 48 percent / 1.) NaH/mineral oil / dimethylformamide / 25 h / 80 °C / 1.) 60 deg C, 2 h

With sodium hydride; hydrazine hydrate; mineral oil; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 124556-78-1
1,6-dichlorophthalazine

: 124556-77-0
8-Chloro-2-{3-[4-(3-chloro-phenyl)-piperazin-1-yl]-propyl}-2H-[1,2,4]triazolo[3,4-a]phthalazin-3-one

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / hydrazine hydrate / ethanol / 1 h / Heating

2: 80 percent / 1 h / 330 - 350 °C

3: 48 percent / 1.) NaH/mineral oil / dimethylformamide / 25 h / 80 °C / 1.) 60 deg C, 2 h

With sodium hydride; hydrazine hydrate; mineral oil; In ethanol; N,N-dimethyl-formamide;