Benzoic acid, 5-fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, Methyl ester

Base Information

• Chemical Name: Benzoic acid, 5-fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, Methyl ester
• CAS No.: 1293284-58-8
• Molecular Formula: C14H20BFO5
• Molecular Weight: 280.104
• Hs Code.: 2934999090
• Mol file: 1293284-58-8.mol

Synonyms:Benzoic acid, 5-fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, Methyl ester;4-Fluoro-2-(Methoxycarbonyl)benzeneboronic acid pinacol ester, 96%;Methyl 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate

Chemical Property of Benzoic acid, 5-fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, Methyl ester

Chemical Property:

• Boiling Point: 365.6±37.0 °C(Predicted)
• PSA: 44.76000
• Density: 1.14±0.1 g/cm3(Predicted)
• LogP: 1.91150
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Methyl5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of Benzoic acid, 5-fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, Methyl ester

There total 5 articles about Benzoic acid, 5-fluoro-2-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-, Methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) + methyl 3-fluoro-6-iodobenzoate (1202897-48-0) → 2,3-dimethyl-2,3-butane diol (76-09-5) + methyl 3-fluorobenzoate (455-68-5) + 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester (1293284-58-8)

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; at 65 ℃; for 1h; Inert atmosphere;

Reference yield: 70.0%

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane (25015-63-8) + methyl 3-fluoro-6-iodobenzoate (1202897-48-0) → 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester (1293284-58-8)

Guidance literature:

With triethylamine; tris-(o-tolyl)phosphine; palladium diacetate; In tetrahydrofuran; at 65 ℃; for 1.16667h; Inert atmosphere;

Reference yield:

bis(pinacol)diborane (73183-34-3) + methyl 3-fluoro-6-iodobenzoate (1202897-48-0) → 5-fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid methyl ester (1293284-58-8)

Guidance literature:

With triethylamine; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; at 65 ℃; for 1h; Inert atmosphere;

upstream raw materials:

bis(pinacol)diborane

methyl 3-fluoro-6-iodobenzoate

5-fluoro-2-iodobenzoic acid

4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane

Downstream raw materials:

methyl 5-fluoro-2-(pyrimidin-2-yl)benzoate

5-fluoro-2-(pyrimidin-2-yl)benzoic acid

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