9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Base Information

Chemical Name:9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
CAS No.:1256579-06-2
Molecular Formula:C19H13BrN2O2
Molecular Weight:381.22272
Hs Code.:
Mol file:1256579-06-2.mol

Synonyms:9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Suppliers and Price of 9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
9-Bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile
250mg
$ 937.00

Total 20 raw suppliers

Chemical Property of 9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Chemical Property:

PSA：76.88000
LogP:4.37798

Purity/Quality:

97% ^*data from raw suppliers

9-Bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses 9-Bromo-6,11-dihydro-8-hydroxy-6,6-dimethyl-11-oxo-5H-benzo[b]carbazole-3-carbonitrile is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Technology Process of 9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

There total 3 articles about 9-broMo-8-hydroxy-6,6-diMethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1256579-03-9
9-bromo-8-methoxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

: 1256579-06-2
9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Guidance literature:: With sodium methylate; 1-dodecylthiol; In 1-methyl-pyrrolidin-2-one; at 160 ℃; for 1h;

Reference yield:

: 1256578-99-0
6-bromo-7-methoxy-1,1-dimethyl-3,4-dihydro-1H-naphthalen-2-one

: 1256579-06-2
9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / 2 h / 100 °C

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran; water / 3 h / 0 °C

3: pyridine hydrochloride / 1.5 h / 190 °C / Microwave irradiation

With pyridine hydrochloride; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; water;
DOI:10.1021/jm200652u

Reference yield:

: 1865-83-4
7-methoxy-1,1-dimethyl-3,4-dihydronaphthalene-2-(1H)-one

: 1256579-06-2
9-bromo-8-hydroxy-6,6-dimethyl-11-oxo-6,11-dihydro-5H-benzo[b]carbazole-3-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: N-Bromosuccinimide / acetonitrile / 2.5 h / 20 °C

2: trifluoroacetic acid / 2 h / 100 °C

3: 2,3-dicyano-5,6-dichloro-p-benzoquinone / tetrahydrofuran; water / 3 h / 0 °C

4: pyridine hydrochloride / 1.5 h / 190 °C / Microwave irradiation

With N-Bromosuccinimide; pyridine hydrochloride; trifluoroacetic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; water; acetonitrile;
DOI:10.1021/jm200652u