2-methoxy-4-[4-(methylsulfonyl)-1-piperazinyl]benzenamine

Base Information

Chemical Name:2-methoxy-4-[4-(methylsulfonyl)-1-piperazinyl]benzenamine
CAS No.:1089283-42-0
Molecular Formula:C₁₂H₁₉N₃O₃S
Molecular Weight:285.367
Hs Code.:
Mol file:1089283-42-0.mol

Synonyms:2-methoxy-4-[4-(methylsulfonyl)-1-piperazinyl]benzenamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methoxy-4-[4-(methylsulfonyl)-1-piperazinyl]benzenamine

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Technology Process of 2-methoxy-4-[4-(methylsulfonyl)-1-piperazinyl]benzenamine

There total 6 articles about 2-methoxy-4-[4-(methylsulfonyl)-1-piperazinyl]benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.5%

: 1089283-41-9
1-(3-methoxy-4-nitrophenyl)-4-(methylsulfonyl)piperazine

: 1089283-42-0
2-methoxy-4-(4-(methylsulfonyl)piperazin-1-yl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 20h; under 760.051 Torr;

Reference yield:

: 448-19-1
4-fluoro-2-methoxy-1-nitrobenzene

: 1089283-42-0
2-methoxy-4-(4-(methylsulfonyl)piperazin-1-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 8 h / 60 °C

2.1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2.2: 1 h / Cooling with ice

3.1: palladium on activated charcoal / dichloromethane / 6 h

With palladium on activated charcoal; potassium carbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 55276-43-2
4-methanesulfonylpiperazine

: 1089283-42-0
2-methoxy-4-(4-(methylsulfonyl)piperazin-1-yl)aniline

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 20 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/acsmedchemlett.0c00338