5-(4-BOC-piperazino)-2-nitroanisole

Base Information

• Chemical Name: 5-(4-BOC-piperazino)-2-nitroanisole
• CAS No.: 1017782-79-4
• Molecular Formula: C16H23N3O5
• Molecular Weight: 337.376
• Mol file: 1017782-79-4.mol

Synonyms:1,1-dimethylethyl 4-[3-(methyloxy)-4-nitrophenyl]-1-piperazinecarboxylate;tert-butyl 4-(3-methoxy-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate;5-(4-BOC-piperazino)-2-nitroanisole;

Chemical Property of 5-(4-BOC-piperazino)-2-nitroanisole

Chemical Property:

• PSA: 87.83000
• LogP: 3.18660

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl4-(3-Methoxy-4-nitrophenyl)tetrahydro-1(2H)-pyrazinecarboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-(4-BOC-piperazino)-2-nitroanisole

There total 5 articles about 5-(4-BOC-piperazino)-2-nitroanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-fluoro-2-methoxy-1-nitrobenzene (448-19-1) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(3-methoxy-4-nitrophenyl)piperazine-1-carboxylate (1017782-79-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 95 ℃; for 20h; Sealed tube;

Reference yield: 92.0%

→ tert-butyl 4-(3-methoxy-4-nitrophenyl)piperazine-1-carboxylate (1017782-79-4)

Guidance literature:

Reference yield: 73.0%

1-chloro-3-methoxy-4-nitrobenzene (6627-53-8) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → tert-butyl 4-(3-methoxy-4-nitrophenyl)piperazine-1-carboxylate (1017782-79-4)

Guidance literature:

With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 12h;

upstream raw materials:

1-chloro-3-methoxy-4-nitrobenzene

1-t-Butoxycarbonylpiperazine

4-fluoro-2-methoxy-1-nitrobenzene

5-fluoro-2-nitrophenol

Downstream raw materials:

tert-butyl 4-(4-amino-3-methoxy-phenyl)-piperazine-1-carboxylate

N₆-cyclohexyl-N₂-[2-methoxy-4-(4-{[3-(morpholin-4-yl)propyl]sulfonyl}piperazin-1-yl)phenyl]-9H-purine-2,6-diamine

C₂₉H₄₀N₈O₃

C₂₅H₃₃N₉O₃

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