(1S)-N-(tert-Butoxycarbonyl)-1-propyl-2-hydroxyethylamine

Base Information

• Chemical Name: (1S)-N-(tert-Butoxycarbonyl)-1-propyl-2-hydroxyethylamine
• CAS No.: 116611-55-3
• Molecular Formula: C₁₀H₂₁NO₃
• Molecular Weight: 203.282
• Mol file: 116611-55-3.mol

Synonyms:(1S)-N-(tert-Butoxycarbonyl)-1-propyl-2-hydroxyethylamine;(S)-[1-(Hydroxymethyl)butyl]carbamic acid 1,1-dimethylethyl ester;[(1S)-1-(Hydroxymethyl)butyl]carbamic acid 1,1-dimethylethyl ester;N-[(1S)-1-(Hydroxymethyl)butyl]carbamic acid tert-butyl ester;CarbaMic acid, N-[(1S)-1-(hydroxyMethyl)butyl]-, 1,1-diMethylethyl ester

Chemical Property of (1S)-N-(tert-Butoxycarbonyl)-1-propyl-2-hydroxyethylamine

Chemical Property:

• Melting Point: 43-45℃
• Boiling Point: 309℃
• PKA: 12.11±0.46(Predicted)
• Flash Point: 141℃
• PSA: 58.56000
• Density: 0.997
• LogP: 2.06300

Purity/Quality:

98%min ^*data from raw suppliers

Carbamicacid,N-[(1S)-1-(hydroxymethyl)butyl]-,1,1-dimethylethylester >98.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1S)-N-(tert-Butoxycarbonyl)-1-propyl-2-hydroxyethylamine

There total 27 articles about (1S)-N-(tert-Butoxycarbonyl)-1-propyl-2-hydroxyethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N-tert-butoxycarbonyl-L-norvaline (53308-95-5) → tert-butyl [(1S)-1-(hydroxymethyl)butyl]carbamate (116611-57-5,116611-55-3)

Guidance literature:

With borane; In tetrahydrofuran; methanol;

Reference yield: 77.0%

C14H25NO6 → tert-butyl [(1S)-1-(hydroxymethyl)butyl]carbamate (116611-57-5,116611-55-3)

Guidance literature:

With sodium tetrahydroborate; In water; at 0 ℃;

DOI:10.1016/j.bmcl.2003.09.088

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + L-norvalinol (22724-81-8,16369-14-5) → tert-butyl [(1S)-1-(hydroxymethyl)butyl]carbamate (116611-57-5,116611-55-3)

Guidance literature:

In dichloromethane;

DOI:10.1016/S0040-4039(99)01081-3

upstream raw materials:

((R)-2-Benzenesulfonyl-1-hydroxymethyl-butyl)-carbamic acid tert-butyl ester

di-tert-butyl dicarbonate

L-norvalinol

N-tert-butoxycarbonyl-L-norvaline

Downstream raw materials:

N-tert-butoxycarbonyl-L-norvaline

(2S)-2-(1,1-dimethylethoxycarbonylamino)pentanal

N-tert-butoxycarbonyl-D-norvaline

(S,E)-tert-butyl 1-(3,5-diamino-6-chloropyrazin-2-yl)-7-(3-(4-methoxyphenyl)propyl)-10,10-dimethyl-1,8-dioxo-4-propyl-9-oxa-2,5,7-triazaundecan-6-ylidenecarbamate