Y320

Base Information

Chemical Name:Y320
CAS No.:288250-47-5
Molecular Formula:C₂₇H₂₉ClN₆O₂
Molecular Weight:505.019
Hs Code.:
Mol file:288250-47-5.mol

Synonyms:Y320;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide;1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide Y320;Y320 1-(4-Chlorophenyl)-N-[3-cyano-4-[4-(4-morpholinyl)-1-piperidinyl]phenyl]-5-methyl-1H-pyrazole-4-carboxamide;Y-320, >=98%;288250-47-5

Suppliers and Price of Y320

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide
25mg
$ 490.00

DC Chemicals
Y-320 >98%
1 g
$ 1900.00

DC Chemicals
Y-320 >98%
250 mg
$ 900.00

DC Chemicals
Y-320 >98%
100 mg
$ 450.00

Crysdot
Y-320 98+%
50mg
$ 352.00

Crysdot
Y-320 98+%
5mg
$ 65.00

Crysdot
Y-320 98+%
10mg
$ 117.00

ChemScene
Y-320 99.39%
100mg
$ 870.00

ChemScene
Y-320 99.39%
50mg
$ 510.00

ChemScene
Y-320 99.39%
10mg
$ 150.00

Total 23 raw suppliers

Chemical Property of Y320

Chemical Property:

Boiling Point:631.2±55.0 °C(Predicted)
PKA:11.82±0.70(Predicted)
PSA：86.42000
Density:1.34±0.1 g/cm3(Predicted)
LogP:4.33498
Storage Temp.:2-8°C
Solubility.:≥24.8 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH

Purity/Quality:

99%, ^*data from raw suppliers

1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Y-320 is an orally active immunomodulator, and inhibits IL-17 production by CD4 T cells stimulated with IL-15 with IC50 of 20 to 60 nM.
Uses 1-(4-Chlorophenyl)-N-(3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl)-5-methyl-1H-pyrazole-4-carboxamide inhibits T cell activation induced by IL-15 and shows a therapeutic effect on collagen-induced arthritis in DBA/1J mice.

Technology Process of Y320

There total 4 articles about Y320 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 187998-35-2
1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid

: 288250-47-5
1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride / 1,2-dichloro-ethane / 1 h / 83 °C

With thionyl chloride; In 1,2-dichloro-ethane;

Reference yield:

: 169548-94-1
1-(4-chlorophenyl)-5-methyl-1H-pyrazole-4-carboxylic acid ethyl ester

: 288250-47-5
1-(4-chlorophenyl)-N-[3-cyano-4-(4-morpholinopiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

2: thionyl chloride / 1,2-dichloro-ethane / 1 h / 83 °C

With thionyl chloride; In 1,2-dichloro-ethane;