TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE

Base Information

Chemical Name:TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE
CAS No.:911227-48-0
Molecular Formula:C18H23NO5
Molecular Weight:0
Hs Code.:
Mol file:911227-48-0.mol

Synonyms:TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE

Suppliers and Price of TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
3,4-DIHYDRO-6-HYDROXY-4-OXO-SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDINE]-1'-CARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER 95.00%
5MG
$ 503.02

Total 1 raw suppliers

Chemical Property of TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE

Chemical Property:

PSA：76.07000
LogP:3.06500

Purity/Quality:

98% ^*data from raw suppliers

3,4-DIHYDRO-6-HYDROXY-4-OXO-SPIRO[2H-1-BENZOPYRAN-2,4'-PIPERIDINE]-1'-CARBOXYLIC ACID-1,1-DIMETHYLETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE

There total 1 articles about TERT-BUTYL 6-HYDROXY-4-OXOSPIRO[CHROMAN-2,4'-PIPERIDINE]-1'-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: 490-78-8
2,5-Dihydroxyacetophenone

: 911227-48-0
tert-butyl 6-hydroxy-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

Guidance literature:: With pyrrolidine; In methanol; at 60 ℃; for 48h;

Reference yield: 83.0%

: 911227-48-0
tert-butyl 6-hydroxy-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

: 74-88-4
methyl iodide

: 936648-32-7
tert-butyl 6-methoxy-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

Guidance literature:: tert-butyl 6-hydroxy-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate; With potassium carbonate; In N,N-dimethyl-formamide; for 0.25h;

methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 20h;
DOI:10.1016/j.bioorg.2019.103210

Reference yield:

: 911227-48-0
tert-butyl 6-hydroxy-4-oxospiro[chroman-2,4′-piperidine]-1′-carboxylate

: 1354927-46-0
C₂₆H₃₃NO₃

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 1 h / 0 °C

2: triethylsilane; trifluoroacetic acid / dichloromethane / 24 h / 20 °C

3: sodium cyanoborohydride; acetic acid / tetrahydrofuran / 5 h / 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 4 h / 65 °C

With triethylsilane; sodium tetrahydroborate; sodium hydride; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.11.038