Lisinopril

Base Information

Chemical Name:Lisinopril
CAS No.:76547-98-3
Molecular Formula:C21H31N3O5
Molecular Weight:405.494
Hs Code.:
European Community (EC) Number:278-488-1,934-016-2
NSC Number:758151,751176
UNII:7Q3P4BS2FD
DSSTox Substance ID:DTXSID6040537
Nikkaji Number:J32.520A
Wikipedia:Lisinopril
Wikidata:Q412208
NCI Thesaurus Code:C29159,C83924
RXCUI:29046,1546022
Pharos Ligand ID:6Y1P65W348W7
Metabolomics Workbench ID:37944
ChEMBL ID:CHEMBL1237
Mol file:76547-98-3.mol

Synonyms:Lisinopril;Lisinopril Maleate (1:1);Lisinopril Sulfate (1:2);Lysinopril;MK-521;Prinivil;Zestril

Suppliers and Price of Lisinopril

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Lisinopril >98%
1 g
$ 150.00

CSNpharm
Lisinopril
5g
$ 215.00

Crysdot
Lisinopril 98+%
5g
$ 208.00

ChemScene
Lisinopril
500mg
$ 80.00

Cayman Chemical
Lisinopril ≥98%
100mg
$ 9.00

Cayman Chemical
Lisinopril ≥98%
500mg
$ 35.00

Cayman Chemical
Lisinopril ≥98%
5g
$ 266.00

Cayman Chemical
Lisinopril ≥98%
1g
$ 61.00

AvaChem
Lisinopril
1g
$ 59.00

AvaChem
Lisinopril
10g
$ 250.00

Total 87 raw suppliers

Chemical Property of Lisinopril

Chemical Property:

Appearance/Colour:white solid
Vapor Pressure:1.14E-18mmHg at 25°C
Melting Point:162-165 °C
Boiling Point:666.4 °C at 760 mmHg
PKA:2.18±0.10(Predicted)
Flash Point:356.9 °C
Density:1.251 g/cm³
Storage Temp.:2-8°C
Solubility.:H2O: ≥10 mg/mL
XLogP3:-2.9
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:12
Exact Mass:405.22637110
Heavy Atom Count:29
Complexity:550

Purity/Quality:

99%, ^*data from raw suppliers

Lisinopril >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 22-24/25

MSDS Files:: SDS file from LookChem

Useful:

Drug Classes:Angiotensin-Converting Enzyme Inhibitors
Canonical SMILES:C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O
Isomeric SMILES:C1C[C@H](N(C1)C(=O)[C@H](CCCCN)N[C@@H](CCC2=CC=CC=C2)C(=O)O)C(=O)O
Recent ClinicalTrials:A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of Hyperkalaemia
Recent EU Clinical Trials:The effects of medication induced blood pressure reduction on cerebral hemodynamics in hypertensive frail elderly
Recent NIPH Clinical Trials:A Study to Evaluate the Effect of Sodium Zirconium Cyclosilicate on Chronic Kidney Disease (CKD) Progression in Participants With CKD and Hyperkalaemia or at Risk of Hyperkalaemia
Description Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM). It reduces the formation of endothelin-1 and increases nitric oxide (NO) in human vascular endothelial cells when used at a concentration of 0.1 nM. Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 μg/kg, respectively).
Uses Labeled Lisinopril, intended for use as an internal standard for the quantification fo Lisinopril by GC- or LC-mass spectrometry. Lisinopril is an antihypertensive medication.
Therapeutic Function Antihypertensive

Technology Process of Lisinopril

There total 20 articles about Lisinopril which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%