Technology Process of 4-Cyano-3-methoxybenzoic acid
There total 8 articles about 4-Cyano-3-methoxybenzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
4-Cyano-3-methoxy-benzoic acid methyl ester;
With
methanol; sodium hydroxide; water;
at 20 ℃;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / Heating / reflux
2: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 50 °C
3: formic acid; hydroxylamine hydrochloride / 25 h / 20 - 50 °C
4: methanol; sodium hydroxide; water / 20 °C
With
methanol; sodium hydroxide; N-Bromosuccinimide; formic acid; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; sodium hydrogencarbonate;
In
dimethyl sulfoxide; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bromine / dichloromethane / 6 h / 0 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C
2.2: 10 h / 0 - 20 °C
3.1: copper(l) iodide; potassium iodide / N,N-dimethyl-formamide / 8 h / 140 °C / Inert atmosphere
4.1: sodium hydroxide / methanol / 1 h / 80 °C
With
copper(l) iodide; bromine; potassium carbonate; potassium iodide; sodium hydroxide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
3.1: |Rosenmund-van Braun Cyanation;
DOI:10.1039/c6tc00153j
