Technology Process of Benzoic acid, 4-cyano-3-Methoxy-
There total 8 articles about Benzoic acid, 4-cyano-3-Methoxy- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-Cyano-3-methoxy-benzoic acid methyl ester;
With
methanol; sodium hydroxide; water;
at 20 ℃;
With
hydrogenchloride;
In
water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / ethyl acetate / Heating / reflux
2: sodium hydrogencarbonate / dimethyl sulfoxide / 3 h / 50 °C
3: formic acid; hydroxylamine hydrochloride / 25 h / 20 - 50 °C
4: methanol; sodium hydroxide; water / 20 °C
With
methanol; sodium hydroxide; N-Bromosuccinimide; formic acid; 2,2'-azobis(isobutyronitrile); hydroxylamine hydrochloride; water; sodium hydrogencarbonate;
In
dimethyl sulfoxide; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bromine / dichloromethane / 6 h / 0 °C
2.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 50 °C
2.2: 10 h / 0 - 20 °C
3.1: copper(l) iodide; potassium iodide / N,N-dimethyl-formamide / 8 h / 140 °C / Inert atmosphere
4.1: sodium hydroxide / methanol / 1 h / 80 °C
With
copper(l) iodide; bromine; potassium carbonate; potassium iodide; sodium hydroxide;
In
methanol; dichloromethane; N,N-dimethyl-formamide;
3.1: |Rosenmund-van Braun Cyanation;
DOI:10.1039/c6tc00153j
