2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile

Base Information

• Chemical Name: 2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile
• CAS No.: 1428477-84-2
• Molecular Formula: C₂₄H₂₄N₂O₅
• Molecular Weight: 420.465
• Mol file: 1428477-84-2.mol

Synonyms:2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile

Chemical Property of 2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile

There total 5 articles about 2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4-cyano-3-methoxyphenyl) acetic acid (1261475-10-8) + 4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidinium chloride (1428478-79-8) → 2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile (1428477-84-2)

Guidance literature:

With pyridine; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidinium chloride (1428478-79-8) + 4-Cyano-3-methoxybenzoic acid (102362-00-5) → 2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile (1428477-84-2)

Guidance literature:

With pyridine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

Reference yield:

ethyl homovanillate (60563-13-5) → 2-methoxy-4-[2-oxo-2-(4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidin-1-yl)ethyl]benzonitrile (1428477-84-2)

Guidance literature:

Multi-step reaction with 4 steps

1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere; Cooling with acetone-dry ice

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 4 h / 80 °C / Inert atmosphere

3: methanol; lithium hydroxide / tetrahydrofuran / 20 °C

4: pyridine; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / dichloromethane / 16 h / 20 °C / Inert atmosphere

With pyridine; methanol; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 1,2-dichloro-ethane; triethylamine; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

(4-cyano-3-methoxyphenyl) acetic acid

4-{[(1-oxo-1,3-dihydro-2-benzofuran-5-yl)oxy]methyl}piperidinium chloride

ethyl (3-methoxy-4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)acetate

ethyl homovanillate