2-cyano-N-(4-methylpyridin-2-yl)acetamide

Base Information

• Chemical Name: 2-cyano-N-(4-methylpyridin-2-yl)acetamide
• CAS No.: 132371-14-3
• Molecular Formula: C9H9N3O
• Molecular Weight: 175.18726
• Hs Code.: 2933399090
• Mol file: 132371-14-3.mol

Synonyms:2-cyano-N-(4-methylpyridin-2-yl)acetamide;2-cyano-N-(4-methyl-2-pyridyl)acetamide;2-cyano-N-(4-methylpyridin-2-yl)ethanamide;IVK/8047421

Chemical Property of 2-cyano-N-(4-methylpyridin-2-yl)acetamide

Chemical Property:

• PSA: 65.78000
• LogP: 1.31518

Purity/Quality:

2-cyano-N-(4-methylpyridin-2-yl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-cyano-N-(4-methylpyridin-2-yl)acetamide

There total 4 articles about 2-cyano-N-(4-methylpyridin-2-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

4-Amino-8-methyl-2H-pyrido<1,2-a>pyrimidin-2-one (132371-11-0) → 2-cyano-N-(4-methylpyridin-2-yl)acetamide (132371-14-3)

Guidance literature:

at 150 - 155 ℃; under 1 Torr;

DOI:10.1007/BF00958262

Reference yield: 42.0%

2-Amino-4-methylpyridine (695-34-1) + cyanoacetic acid (372-09-8) → 2-cyano-N-(4-methylpyridin-2-yl)acetamide (132371-14-3)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00263

Reference yield: 27.0%

2-Amino-4-methylpyridine (695-34-1) + ethyl 2-cyanoacetate (105-56-6) → 2-cyano-N-(4-methylpyridin-2-yl)acetamide (132371-14-3)

Guidance literature:

at 130 - 145 ℃; under 60 Torr;

DOI:10.1007/BF00959647

upstream raw materials:

2-Amino-4-methylpyridine

ethyl 2-cyanoacetate

4-Amino-8-methyl-2H-pyrido<1,2-a>pyrimidin-2-one

cyanoacetic acid