BENZENEETHANIMIDAMIDE, N-HYDROXY-3,5-DIMETHOXY

Base Information

• Chemical Name: BENZENEETHANIMIDAMIDE, N-HYDROXY-3,5-DIMETHOXY
• CAS No.: 903094-85-9
• Molecular Formula: C10H14N2O3
• Molecular Weight: 0
• Mol file: 903094-85-9.mol

Synonyms:BENZENEETHANIMIDAMIDE, N-HYDROXY-3,5-DIMETHOXY

Chemical Property of BENZENEETHANIMIDAMIDE, N-HYDROXY-3,5-DIMETHOXY

Chemical Property:

• PSA: 74.57000
• LogP: 1.69300

Purity/Quality:

BENZENEETHANIMIDAMIDE,N-HYDROXY-3,5-DIMETHOXY 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BENZENEETHANIMIDAMIDE, N-HYDROXY-3,5-DIMETHOXY

There total 2 articles about BENZENEETHANIMIDAMIDE, N-HYDROXY-3,5-DIMETHOXY which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,5-dimethoxyphenylacetonitrile (13388-75-5) → (Z)-2-(3,5-dimethoxyphenyl)-N'-hydroxyacetimidamide (903094-85-9)

Guidance literature:

With hydroxylamine; In ethanol; water; at 20 ℃; for 5h;

DOI:10.1021/jm500066b

Reference yield:

→ C10H14N2O3 (903094-85-9)

Guidance literature:

With hydroxylamine; In ethanol; water; for 5h; Reflux;

Reference yield: 10.0%

3-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)benzo[b]thiophene-2-carboxylic acid (1416051-63-2) + (Z)-2-(3,5-dimethoxyphenyl)-N'-hydroxyacetimidamide (903094-85-9) → tert-butyl 4-((2-(3-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-5-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate (1581303-51-6)

Guidance literature:

3-((1-(tert-butoxycarbonyl)piperidin-4-yl)oxy)benzo[b]thiophene-2-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

(Z)-2-(3,5-dimethoxyphenyl)-N'-hydroxyacetimidamide; In N,N-dimethyl-formamide; at 140 ℃; for 3h;

DOI:10.1021/jm500066b

upstream raw materials:

3,5-dimethoxyphenylacetonitrile

Downstream raw materials:

tert-butyl 4-((2-(3-(3,5-dimethoxybenzyl)-1,2,4-oxadiazol-5-yl)benzo[b]thiophen-3-yl)oxy)piperidine-1-carboxylate

3-(3,5-dimethoxybenzyl)-5-(3-(piperidin-4-yloxy)benzo[b]thiophen-2-yl)-1,2,4-oxadiazole