(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)

Base Information Edit

Chemical Name:(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)
CAS No.:131359-24-5
Molecular Formula:C₁₇H₁₄O₃
Molecular Weight:266.296
Hs Code.:
Mol file:131359-24-5.mol

Synonyms:(E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA);(1E,4E)-1,5-Bis(2-Hydroxyphenyl)-1,4-pentadien-3-one;HBB2;2-HBA

Suppliers and Price of (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(E,E)-Bis(2-hydroxybenzylidene)acetone(2-HBA)
25mg
$ 185.00

TRC
(E,E)-Bis(2-hydroxybenzylidene)acetone(2-HBA)
50mg
$ 335.00

Sigma-Aldrich
HBB2 ≥98% (HPLC)
5mg
$ 82.00

Sigma-Aldrich
HBB2 ≥98% (HPLC)
25mg
$ 318.00

DC Chemicals
2-HBA >98%
100 mg
$ 450.00

CSNpharm
2-HBA
5mg
$ 40.00

CSNpharm
2-HBA
100mg
$ 300.00

Cayman Chemical
2-HBA ≥98%
50mg
$ 416.00

Cayman Chemical
2-HBA ≥98%
10mg
$ 99.00

Cayman Chemical
2-HBA ≥98%
5mg
$ 52.00

Total 7 raw suppliers

Chemical Property of (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) Edit

Chemical Property:

PSA：57.53000
LogP:3.39350
Storage Temp.:?20°C
Solubility.:DMSO: soluble15mg/mL (clear solution)

Purity/Quality:

99%+, ^*data from raw suppliers

(E,E)-Bis(2-hydroxybenzylidene)acetone(2-HBA) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description Nrf2 activation of the antioxidant response element (ARE) is central to cytoprotective gene expression against oxidative and/or electrophilic stress. Unless activated by inflammatory, environmental, or oxidative stressors, Nrf2 is sequestered in the cytoplasm by its repressor, Keap1. Because of its protective capabilities, small molecules that activate Nrf2 signaling are being examined as potential anti-cancer or anti-inflammatory agents. 2-HBA, a synthetic analog of curcumin, is an indirect inducer of enzymes that catalyze detoxification reactions through the Keap1-Nrf2-ARE pathway. As a double Michael reaction acceptor, 2-HBA can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination, which leads to enhanced expression of antioxidative and cytoprotective enzymes. 2-HBA doubles the specific activity of NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1) in Hepa1c1c7 cells at 0.15 μM. In rapidly dividing mouse leukemia L1210 cells, 0.6 μM 2-HBA increases the activities of NQO1, glutathione reductase, and the levels of total glutathione. At 5-15 μM, 2-HBA causes G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.
Uses (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) is a synthetic analogue of curcumin that displays strong NAD(P)H:quinone reductase (NQO1) inducer potency in Hepa 1c1c7 cells. 2-HBA, a double Michael reaction acceptor, can directly modify cysteine sulfhydryl groups in Keap1 and consequently suppress Nrf2 ubiquitination which in turn enhances the expression of antioxidative and cytoprotective enzymes. 2-HBA has also been shown to cause G2/M cell cycle arrest and p53-independent, caspase 3-mediated apoptosis.

Technology Process of (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA)

There total 11 articles about (E,E)-Bis(2-hydroxybenzylidene)acetone (2-HBA) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%