(6,11-Dihydro-5H-dibenzo[b,e]azepin-6-yl)methanamine fumarate

Base Information

Chemical Name:(6,11-Dihydro-5H-dibenzo[b,e]azepin-6-yl)methanamine fumarate
CAS No.:80012-79-9
Molecular Formula:C₄H₄O₄*C₁₅H₁₆N₂
Molecular Weight:340.379
Hs Code.:
European Community (EC) Number:685-627-3

Synonyms:127785-96-0;(6,11-Dihydro-5H-dibenzo[b,e]azepin-6-yl)methanamine fumarate;6-Aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepine (E)-2-butenedioate;80012-79-9;(E)-but-2-enedioic acid;6,11-dihydro-5H-benzo[c][1]benzazepin-6-ylmethanamine;5H-Dibenz[b,e]azepine-6-methanamine, 6,11-dihydro-, (2E)-2-butenedioate (1:1);MFCD11865145;SCHEMBL5367297;SCHEMBL11256018;(6,11-Dihydro-5H-dibenzo[b,e]azepin-6-yl)methanaminefumarate;BCP13637;AKOS015900707;BS-14927;CS-0155926;A857230;6,11-dihydro-5H-benzo[c][1]benzazepin-6-ylmethylazanium;(E)-4-hydroxy-4-oxobut-2-enoate

Suppliers and Price of (6,11-Dihydro-5H-dibenzo[b,e]azepin-6-yl)methanamine fumarate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 14 raw suppliers

Chemical Property of (6,11-Dihydro-5H-dibenzo[b,e]azepin-6-yl)methanamine fumarate

Chemical Property:

Vapor Pressure:4.48E-16mmHg at 25°C
Boiling Point:616.9°C at 760 mmHg
Flash Point:326.9°C
PSA：112.65000
LogP:3.25280
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:340.14230712
Heavy Atom Count:25
Complexity:372

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1C2=CC=CC=C2C(NC3=CC=CC=C31)CN.C(=CC(=O)O)C(=O)O
Isomeric SMILES:C1C2=CC=CC=C2C(NC3=CC=CC=C31)CN.C(=C/C(=O)O)\C(=O)O

Technology Process of (6,11-Dihydro-5H-dibenzo[b,e]azepin-6-yl)methanamine fumarate

There total 6 articles about (6,11-Dihydro-5H-dibenzo[b,e]azepin-6-yl)methanamine fumarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.1%

: 74860-00-7
N-<(11H-dibenzazepin-6-yl)methyl>phthalimide

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 127785-96-0,80012-79-9
6,11-dihydro-5H-dibenzazepine-6-methanamine fumarate

Guidance literature:: N-<(11H-dibenzazepin-6-yl)methyl>phthalimide; With sodium tetrahydroborate; In methanol; water; isopropyl alcohol; toluene; at 20 - 30 ℃; for 24.5h;

With hydrogenchloride; In water; isopropyl alcohol; at 20 - 80 ℃; for 1.5h;

(2E)-but-2-enedioic acid; With sodium hydroxide; more than 3 stages; Product distribution / selectivity;

Reference yield: 76.0%

: 41218-84-2
6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine

: 110-17-8,26099-09-2
(2E)-but-2-enedioic acid

: 127785-96-0,80012-79-9
6,11-dihydro-5H-dibenzazepine-6-methanamine fumarate

Guidance literature:: In methanol; at 20 ℃; for 1h;

Reference yield:

: 21535-43-3
N-[2-(phenylmethyl)phenyl]-2-chloroacetamide

: 127785-96-0,80012-79-9
6,11-dihydro-5H-dibenzazepine-6-methanamine fumarate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / toluene / 6 h / 65 - 90 °C

2.1: potassium hydroxide / N,N-dimethyl-formamide / 55 °C

2.2: 15 h / 45 °C

3.1: formic acid; hydrogen; 5%-palladium/activated carbon / N,N-dimethyl-formamide / 24 h / 70 °C / 7500.75 Torr

4.1: hydrogenchloride / glycerol; water / 2.5 h / 20 - 110 °C

5.1: methanol / 1 h / 20 °C

With hydrogenchloride; formic acid; 5%-palladium/activated carbon; hydrogen; potassium hydroxide; trichlorophosphate; In methanol; water; N,N-dimethyl-formamide; glycerol; toluene;