21535-43-3

Basic information

• Product Name: N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide
• Synonyms: N-2-(PHENYLMETHYL)PHENYL-2-CHLOROACETAMIDE;N-(2-Benzyl-phenyl)-2-chloro-acetamide;2-Chloro-N-[2-(benzyl)phenyl]acetamide;2-Chloro-α-phenyl-o-acetotoluidide
• CAS NO: 21535-43-3
• Molecular Formula: C₁₅H₁₄ClNO
• Molecular Weight: 259.73
• Product Categories: Aromatics;Miscellaneous Reagents
• Mol File: 21535-43-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 113-114 °C
• Boiling Point: 443.2 °C at 760 mmHg
• Flash Point: 221.8 °C
• Appearance: /
• Density: 1.217 g/cm³
• Vapor Pressure: 4.73E-08mmHg at 25°C
• Refractive Index: 1.617
• Storage Temp.: 2-8°C
• Solubility: Chloroform
• PKA: 12.89±0.70(Predicted)
• CAS DataBase Reference: N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide(21535-43-3)
• EPA Substance Registry System: N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide(21535-43-3)

Safety Data

• Hazardous Substances Data: 21535-43-3(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

Uses

2-Chloro-N-[2-(benzyl)phenyl]acetamide (cas# 21535-43-3) is a compound useful in organic synthesis.

InChI:InChI=1/C15H14ClNO/c16-11-15(18)17-14-9-5-4-8-13(14)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,17,18)

Upstream product

• 28059-64-5 2-benzylaniline 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 108929-04-0 epinastine hydrochloride 
• 706753-75-5 9H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine 
• 127786-29-2 3-amino-9,13b-dihydro-1H-dibenzimidazo<1,5-a>azepine hydrobromide 
• 127785-96-0 6,11-dihydro-5H-dibenzazepine-6-methanamine fumarate 
• 41218-84-2 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine 
• 112247-76-4 N,N-diethyl-N'-(2-benzyl-phenyl)-N'-methyl-ethylenediamine 
• 109935-24-2 N,N-diethyl-N'-(2-benzyl-phenyl)-ethylenediamine 
• 21535-44-4 6-(chloromethyl)-11H-dibenzazepine 
• 74859-96-4 2-azido-α-phenyl-o-acetotoluidine 
• 74859-97-5 2-amino-α-phenyl-o-acetotoluidine 
• 118989-63-2 N-(2-benzylphenyl)-2-(4-methyl-1-piperazinyl)acetamide 
• 807282-02-6 N,N-diethyl-glycine-(2-benzyl-anilide) 
• 74859-98-6 2-acetamido-α-phenyl-o-acetotoluidine 
• 642442-03-3 N-(11H-dibenzo[b,e]azepin-6-ylmethyl)-N-[(1'S)-1'-phenylethyl]amine 

Relevant articles and documents

Novel method of preparing Epinastine

The present invention relates to a novel manufacturing method for synthesizing an anti-histamine pharmaceutical medicine, epinastine. The novel manufacturing method for synthesizing epinastine according to the present invention has fewer synthesizing steps than a conventional epinastine manufacturing method, and is a safe synthesis method, thereby being expected to be used for inexpensively synthesizing the anti-histamine pharmaceutical medicine, epinastine by the manufacturing method, and supplying the same to the market.COPYRIGHT KIPO 2020

Stereoselective synthesis of (R)-(-)-mianserin

(14bR)-2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine, (R)-(-)-mianserin 1a was synthesised in several steps in good enantiomeric purity with the use of (S)-(-)-α-methylbenzylamine 5. The absolute configuration was assigned on the bas