21535-43-3

Usage

Uses

Used in Organic Synthesis:
N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide is used as a synthetic building block for the creation of various complex organic molecules. Its unique structure allows for a wide range of chemical reactions, making it a valuable starting material for the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide is used as an intermediate in the development of new drugs. Its chemical properties and reactivity enable the creation of novel drug candidates with potential therapeutic applications. The compound's versatility in organic synthesis allows for the exploration of various structural modifications to optimize the drug's efficacy, safety, and pharmacokinetic properties.
Used in Agrochemical Industry:
N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide is also utilized in the agrochemical industry for the synthesis of new pesticides and other crop protection agents. Its unique chemical structure can be tailored to target specific pests or diseases, leading to the development of more effective and environmentally friendly agrochemicals.
Used in Chemical Research:
In the field of chemical research, N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide serves as a valuable research tool for studying various chemical reactions and mechanisms. Its reactivity and structural features make it an ideal candidate for exploring new synthetic routes, reaction conditions, and catalysts, ultimately contributing to the advancement of organic chemistry.

InChI:InChI=1/C15H14ClNO/c16-11-15(18)17-14-9-5-4-8-13(14)10-12-6-2-1-3-7-12/h1-9H,10-11H2,(H,17,18)

Upstream product

• 28059-64-5 2-benzylaniline 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 807282-02-6 N,N-diethyl-glycine-(2-benzyl-anilide) 
• 118989-63-2 N-(2-benzylphenyl)-2-(4-methyl-1-piperazinyl)acetamide 
• 74859-97-5 2-amino-α-phenyl-o-acetotoluidine 
• 74859-96-4 2-azido-α-phenyl-o-acetotoluidine 
• 21535-44-4 6-(chloromethyl)-11H-dibenzazepine 
• 109935-24-2 N,N-diethyl-N'-(2-benzyl-phenyl)-ethylenediamine 
• 112247-76-4 N,N-diethyl-N'-(2-benzyl-phenyl)-N'-methyl-ethylenediamine 
• 108929-04-0 epinastine hydrochloride 
• 706753-75-5 9H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine 
• 127786-29-2 3-amino-9,13b-dihydro-1H-dibenzimidazo<1,5-a>azepine hydrobromide 
• 127785-96-0 6,11-dihydro-5H-dibenzazepine-6-methanamine fumarate 
• 41218-84-2 6-aminomethyl-6,11-dihydro-5H-dibenzo[b,e]azepine 
• 74859-98-6 2-acetamido-α-phenyl-o-acetotoluidine 
• 642442-03-3 N-(11H-dibenzo[b,e]azepin-6-ylmethyl)-N-[(1'S)-1'-phenylethyl]amine 

Relevant academic research and scientific papers

Novel method of preparing Epinastine

The present invention relates to a novel manufacturing method for synthesizing an anti-histamine pharmaceutical medicine, epinastine. The novel manufacturing method for synthesizing epinastine according to the present invention has fewer synthesizing steps than a conventional epinastine manufacturing method, and is a safe synthesis method, thereby being expected to be used for inexpensively synthesizing the anti-histamine pharmaceutical medicine, epinastine by the manufacturing method, and supplying the same to the market.COPYRIGHT KIPO 2020

A facile synthesis of epinastine HCl via dehydroepinastine intermediate

Epinastine is a second generation histamine H1 receptor antagonist used as a non-sedative antiallergic drug. When given orally, epinastine poorly penetrates blood-brain barrier (BBB) and appears to be free of cardiac toxicity as compared to other antihistamine drugs. A couple of synthetic approaches for epinastine HCl have been reported so far. They hold several problems such as explosive, highly toxic or expensive reagents. Moreover, they usually do not offer concise synthetic steps. In our synthesis shown here, a commonly used starting material, 6-(chloromethyl)-11H-dibenzo[b,e]azepine is treated with cyanamide to afford dehydroepinastine (14) in significantly high yield, which is subsequently reduced in the presence of aqueous HCl to give epinastine HCl in only two steps (75% overall yield for two steps). The problems associated with the reported processes such as using toxic and dangerous chemicals, lengthy synthetic steps or low overall product yields can be overcome by utilizing this new route. We believe our synthetic scheme might provide a breakthrough to reduce the cost of the production of epinastine HCl.

Stereoselective synthesis of (R)-(-)-mianserin

(14bR)-2-Methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyrazino[1,2-a]azepine, (R)-(-)-mianserin 1a was synthesised in several steps in good enantiomeric purity with the use of (S)-(-)-α-methylbenzylamine 5. The absolute configuration was assigned on the bas