ETHYL 4-(ETHYLTHIO)BENZOYLFORMATE

Base Information

• Chemical Name: ETHYL 4-(ETHYLTHIO)BENZOYLFORMATE
• CAS No.: 300355-73-1
• Molecular Formula: C₁₂H₁₄O₃S
• Molecular Weight: 238.307
• Hs Code.: 2930909090
• Mol file: 300355-73-1.mol

Synonyms:ETHYL 4-(ETHYLTHIO)BENZOYLFORMATE

Chemical Property of ETHYL 4-(ETHYLTHIO)BENZOYLFORMATE

Chemical Property:

• Vapor Pressure: 2.98E-05mmHg at 25°C
• Boiling Point: 356.2°C at 760 mmHg
• Flash Point: 169°C
• PSA: 68.67000
• Density: 1.17g/cm³
• LogP: 2.54440

Purity/Quality:

97% ^*data from raw suppliers

(4-Ethylsulfanylphenyl)oxoaceticacidethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 4-(ETHYLTHIO)BENZOYLFORMATE

There total 1 articles about ETHYL 4-(ETHYLTHIO)BENZOYLFORMATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

Ethyl phenyl sulfide (622-38-8) + Ethyl oxalyl chloride (4755-77-5) → ethyl 2-(4-(ethylthio)phenyl)-2-oxoacetate (300355-73-1)

Guidance literature:

With aluminum (III) chloride; In chloroform; at 0 ℃; for 3.5h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00783

Reference yield: 88.0%

ethyl 2-(4-(ethylthio)phenyl)-2-oxoacetate (300355-73-1) → ethyl 2-(4-(ethylsulfonyl)phenyl)-2-oxoacetate

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/acs.jmedchem.8b00783

Reference yield:

ethyl 2-(4-(ethylthio)phenyl)-2-oxoacetate (300355-73-1) → ethyl 2-((tert-butoxycarbonyl)amino)-2-(4-(ethylsulfonyl)phenyl)acetate

Guidance literature:

Multi-step reaction with 3 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride / ethanol / 2 h / 80 °C / Inert atmosphere

3.1: palladium 10% on activated carbon; hydrogen / ethanol / 16 h / 20 °C

3.2: 5 h / 20 °C

With palladium 10% on activated carbon; hydroxylamine hydrochloride; hydrogen; 3-chloro-benzenecarboperoxoic acid; In ethanol; dichloromethane;

DOI:10.1021/acs.jmedchem.8b00783

upstream raw materials:

Ethyl phenyl sulfide

Ethyl oxalyl chloride

Refernces

• 1、 -. "DIHYDROPYRROLOPYRIDINE INHIBITORS OF ROR-GAMMA". Paragraph 00161. . Retrieved 2016/05/24.
• 2、 -. "HETEROAROMATIC GLUCOKINASE ACTIVATORS". . . Retrieved 2008/06/13.