N-(2-Chlorobenzyl)-N-phenylamine

Base Information

• Chemical Name: N-(2-Chlorobenzyl)-N-phenylamine
• CAS No.: 41001-24-5
• Molecular Formula: C13H12ClN
• Molecular Weight: 217.698
• Hs Code.: 2921499090
• Mol file: 41001-24-5.mol

Synonyms:N-(2-Chlorobenzyl)-N-phenylamine;(2-chlorobenzyl)-phenyl-amine

Chemical Property of N-(2-Chlorobenzyl)-N-phenylamine

Chemical Property:

• Boiling Point: 337.6±17.0 °C(Predicted)
• PKA: 3.52±0.50(Predicted)
• PSA: 12.03000
• Density: 1.199±0.06 g/cm3(Predicted)
• LogP: 4.02510

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Chlorobenzyl)-N-phenylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

Useful:

Technology Process of N-(2-Chlorobenzyl)-N-phenylamine

There total 25 articles about N-(2-Chlorobenzyl)-N-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

aniline (62-53-3) + sodium (2-chlorophenyl)(hydroxy)methanesulfonate → N-(2-chlorobenzyl)aniline (41001-24-5)

Guidance literature:

With 2-picoline borane complex; In methanol; water; at 60 ℃; for 16h; Sealed tube; Inert atmosphere;

DOI:10.1021/acs.orglett.1c02604

Reference yield: 96.0%

2-chloro-benzaldehyde (89-98-5) + aniline (62-53-3) → N-(2-chlorobenzyl)aniline (41001-24-5)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; at 20 ℃; for 0.116667h;

DOI:10.3906/kim-0903-46

Reference yield: 93.0%

1-chloro-2-(chloromethyl)benzene (611-19-8) + Formanilid (103-70-8) → N-(2-chlorobenzyl)aniline (41001-24-5)

Guidance literature:

With potassium hydroxide; In water; at 50 ℃; for 3h; Green chemistry;

DOI:10.1016/j.tet.2013.12.031

upstream raw materials:

2-chlorobenzalaniline

2-Amino-1,8-naphthyridine-3-carboxamide

1-chloro-2-(chloromethyl)benzene

aniline

Downstream raw materials:

2-[(1E)-2-(2-chlorophenyl)ethenyl]quinoline

2-(2-chlorophenyl)quinazolin-4(3H)-one

phenanthridine

N-benzoyl-(6H)phenanthridine

Refernces

• 1、 Zhu, Guanxin,Duan, Zheng-Chao,Zhu, Haiyan,Ye, Dongdong,Wang, Dawei. "Selective C-C bonds formation, N-alkylation and benzo[d]imidazoles synthesis by a recyclable zinc composite". supporting information. p. 266 - 270. Retrieved 2021/08/06.
• 2、 Huang, Ming,Huang, Yong-Liang,Ke, Zhuofeng,Lan, Xiao-Bing,Li, Weikang,Liu, Jiahao,Liu, Yan,Ye, Zongren,Zhao, Cunyuan. "Enhanced Hydride Donation Achieved Molybdenum Catalyzed Direct N-Alkylation of Anilines or Nitroarenes with Alcohols: From Computational Design to Experiment". . p. 10377 - 10382. Retrieved 2021/08/31.