Formanilide

Base Information

• Chemical Name: Formanilide
• CAS No.: 103-70-8
• Molecular Formula: C7H7 N O
• Molecular Weight: 121.139
• Hs Code.: 29242990
• European Community (EC) Number: 203-136-0
• NSC Number: 8862
• UNII: 2805XEA9CL
• DSSTox Substance ID: DTXSID3025338
• Nikkaji Number: J28.435A
• Wikipedia: Formanilide
• Wikidata: Q2689660
• ChEMBL ID: CHEMBL1232659
• Mol file: 103-70-8.mol

Synonyms:formanilide;N-phenylformamide

Chemical Property of Formanilide

Chemical Property:

• Appearance/Colour: white or light yellow crystals or powder
• Vapor Pressure: 0.00662mmHg at 25°C
• Melting Point: 46-48 °C(lit.)
• Refractive Index: 1.5908 (estimate)
• Boiling Point: 166 °C14 mm Hg(lit.)
• PKA: 15.00±0.70(Predicted)
• Flash Point: 150.2°C
• PSA: 29.10000
• Density: 1.14g/cm³
• LogP: 1.96380
• Storage Temp.: Store below +30°C.
• Solubility.: water: soluble25.4g/L at 20°C
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 121.052763847
• Heavy Atom Count: 9
• Complexity: 86.9

Purity/Quality:

99% ^*data from raw suppliers

Formanilide >99.0%(GC) ^*data from reagent suppliers

Safty Information:

• Statements: 22
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Aromatics (Nitrogen)
• Canonical SMILES: C1=CC=C(C=C1)NC=O
• Uses: Formanilide was used to study the zero electron kinetic energy(ZEKE) spectra of cis- and trans-formanilide. It was used to investigate the gas-phase structures of the two isomers of the trans-formanilide-water complex by two-colour (1+1′) resonance enhanced multiphoton ionisation (REMPI) and ZEKE spectroscopy.

Technology Process of Formanilide

There total 321 articles about Formanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl N-formylpyroglutamate (114554-56-2) + aniline (62-53-3) → methyl 5-oxopyrrolidine-2-carboxylate (4931-66-2,54571-66-3,64700-65-8) + Formanilid (103-70-8)

Guidance literature:

With triethylamine; In toluene; for 4h; Product distribution; Heating;

DOI:10.1002/jhet.5570250108

Reference yield: 70.0%

N-ethyl-N-phenylamine (103-69-5) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + Formanilid (103-70-8)

Guidance literature:

With sodium hydroxide; potassium hexacyanoferrate(III); In methanol; water; at 35 ℃; for 24h; Rate constant; Mechanism;

Reference yield: 70.0%

N,N-diethylaniline (91-66-7) → formaldehyd (50-00-0,30525-89-4,61233-19-0) + acetaldehyde (75-07-0,9002-91-9) + Formanilid (103-70-8)

Guidance literature:

With sodium hydroxide; potassium hexacyanoferrate(III); In methanol; water; at 35 ℃; for 24h;

upstream raw materials:

pyridine

formic acid

aniline

N-phenylpyrrolidine

Downstream raw materials:

5-anilinomethylene-1,3-diphenyl-pyrimidine-2,4,6-trione

N-formyl-N-phenyl-N'-(toluene-4-sulfonyl)-urea

N-phenyl benzoyl amide

N,N'-diphenyl-N-formylurea

Refernces

• 1、 Kondo et al.. "". . p. 853. Retrieved 1973.
• 2、 Liu, Jiewei,Fan, Yan-Zhong,Zhang, Kun,Zhang, Li,Su, Cheng-Yong. "Engineering Porphyrin Metal-Organic Framework Composites as Multifunctional Platforms for CO2Adsorption and Activation". . p. 14548 - 14556. Retrieved 2020.
• 3、 Yue, Chengtao,Wang, Wenlong,Li, Fuwei. "Building N-Heterocyclic Carbene into Triazine-Linked Polymer for Multiple CO2 Utilization". . p. 5996 - 6004. Retrieved 2020.
• 4、 Fukumoto, Yoshiya,Shiratani, Motohiro,Noguchi, Hikaru,Chatani, Naoto. "Iridium-Catalyzed Direct Amidation of Imidazoles at the C-2 Position with Isocyanates in the Presence of Hydrosilanes Leading to Imidazole-2-Carboxamides". . p. 3011 - 3018. Retrieved 2021.
• 5、 Marjani, Ahmad Poursattar,Hosseini, Seyed Ali,Shokri, Zahra,Maleki, Nasim. "Co3O4 nanoparticles prepared by oxidative precipitation method: an efficient and reusable heterogeneous catalyst for N-formylation of amines". . p. 413 - 422. Retrieved 2017.
• 6、 Duan, Yanan,Song, Tao,Dong, Xiaosu,Yang, Yong. "Enhanced catalytic performance of cobalt nanoparticles coated with a N,P-codoped carbon shell derived from biomass for transfer hydrogenation of functionalized nitroarenes". . p. 2821 - 2828. Retrieved 2018.
• 7、 Zhang, Rui,Zhang, Jun-Chao,Zhang, Wei-Yi,He, Yu-Qing,Cheng, Hua,Chen, Cheng,Gu, Yu-Cheng. "A Practical Approach for the Transamidation of N, N-Dimethyl Amides with Primary Amines Promoted by Sodium tert-Butoxide under Solvent-Free Conditions". . p. 3286 - 3294. Retrieved 2020.
• 8、 Preedasuriyachai, Patcharee,Chavasiri, Warinthorn,Sakurai, Hidehiro. "Aerobic oxidation of cyclic amines to lactams catalyzed by PVP-stabilized nanogold". . p. 1121 - 1124. Retrieved 2011.
• 9、 Kumar Kar, Ashish,Srivastava, Rajendra. "Reductive Formylation of Nitroarenes using HCOOH over Bimetallic C?N Framework Derived from the Integration of MOF and COF". . p. 3174 - 3183. Retrieved 2021.
• 10、 Srinivasan,Boyer. "". . p. 379. Retrieved 1974.