Technology Process of 3,6-Dichloropyrazine-2-carbaldehyde
There total 1 articles about 3,6-Dichloropyrazine-2-carbaldehyde which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2,5-dichloropyrazine;
With
2,2,6,6-tetramethylpiperidinylmagnesium chloride; lithium chloride;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 1h;
4-morpholinecarboxaldehyde;
In
tetrahydrofuran; toluene;
at -78 ℃;
for 2h;
DOI:10.1016/j.tetlet.2011.12.018
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: dichloromethane / 16 h / 22 °C
2.1: sodium tetrahydroborate / ethanol / 3 h / 22 °C
2.2: 4 h / Reflux
3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); potassium carbonate;
In
1,4-dioxane; ethanol; dichloromethane; water;
1.1: Wittig reaction / 3.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.12.018
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: dichloromethane / 16 h / 22 °C
2.1: sodium tetrahydroborate / ethanol / 3 h / 22 °C
2.2: 4 h / Reflux
3.1: tetrakis(triphenylphosphine) palladium(0); potassium carbonate / 1,4-dioxane; water / 3 h / 100 °C / Inert atmosphere
4.1: trifluoroacetic acid / dichloromethane / 1 h / 22 °C
4.2: 2 h / 22 °C
With
sodium tetrahydroborate; tetrakis(triphenylphosphine) palladium(0); potassium carbonate; trifluoroacetic acid;
In
1,4-dioxane; ethanol; dichloromethane; water;
1.1: Wittig reaction / 3.1: Suzuki coupling;
DOI:10.1016/j.tetlet.2011.12.018
