4394-85-8 Usage
Chemical Properties
CLEAR YELLOW LIQUID
Uses
Different sources of media describe the Uses of 4394-85-8 differently. You can refer to the following data:
1. 4-Formylmorpholine is widely used as a solvent and extracting agent for aromatics. It is used as a scrubbing agent for acidic gases. It is employed in the preparation of adenine hydrochloride labeled with 14C, 4-(trifluoromethyl)morpholine, 3-alkyl-2-chloro-5,6-dihydrobenzaldehyde and terphenyl dialdehyde. It plays an important role in the desulfurization of natural gas, synthetic gas, flue gas and gasoline.
2. 4-Formylmorpholine has been used in the preparation of:adenine hydrochloride labelled with 14Cterphenyl dialdehyde
Synthesis Reference(s)
The Journal of Organic Chemistry, 25, p. 199, 1960 DOI: 10.1021/jo01072a012
General Description
Treatment of 4-formylmorpholine with sulphur tetrafluoride in the presence of potassium fluoride gives 4-(trifluoromethyl)morpholine in excellent yields. 4-Formylmorpholine reacts with series of 2-alkyl-2-cyclohexen-1-ones in the presence of POCl3 to give the corresponding 3-alkyl-2-chloro-5,6-dihydrobenzaldehydes and allylic alcohols (by-product).
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 4394-85-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,3,9 and 4 respectively; the second part has 2 digits, 8 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4394-85:
(6*4)+(5*3)+(4*9)+(3*4)+(2*8)+(1*5)=108
108 % 10 = 8
So 4394-85-8 is a valid CAS Registry Number.
InChI:InChI=1/C5H9NO2/c7-5-6-1-3-8-4-2-6/h5H,1-4H2
4394-85-8Relevant articles and documents
Confirmation by trapping, synthesis, and reactivity of 2,3-dehydro-N-methylmorpholine (DNMM)
Liebner, Falk,Schmid, Peter,Adelw?hrer, Christian,Rosenau, Thomas
, p. 11817 - 11821 (2007)
The elusive 4-methyl-3,4-dihydro-2H-[1,4]oxazine (2,3-dehydro-N-methylmorpholine, DNMM, 5) was confirmed to occur as degradation product of N-methylmorpholine-N-oxide (1) by trapping with the α-tocopherol-derived ortho-quinone methide in a hetero-Diels-Alder reaction with inverse electron demand. The regioselectivity of the addition was in good agreement with DFT computational data. An authentic sample of 5 was synthesized from formmorpholide (16) via 2-methoxy-formmorpholide in 38% overall yield.
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Nefedov,B.K. et al.
, (1973)
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Nickel-Catalyzed Amination of Aryl Chlorides with Amides
Li, Jinpeng,Huang, Changyu,Wen, Daheng,Zheng, Qingshu,Tu, Bo,Tu, Tao
supporting information, p. 687 - 691 (2021/01/09)
A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.
Solvent-free, Efficient Transamidation of Carboxamides with Amines Catalyzed by Recyclable Sulfated Polyborate Catalyst
Mali, Anil S.,Indalkar, Krishna,Chaturbhuj, Ganesh U.
, p. 369 - 378 (2021/07/26)
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