benzyl5-forMyl-2,2-diMethyl-1,3-dioxan-5-ylcarbaMate

Base Information

• Chemical Name: benzyl5-forMyl-2,2-diMethyl-1,3-dioxan-5-ylcarbaMate
• CAS No.: 1313876-83-3
• Molecular Formula: C15H19NO5
• Molecular Weight: 293.31506
• Mol file: 1313876-83-3.mol

Synonyms:benzyl5-forMyl-2,2-diMethyl-1,3-dioxan-5-ylcarbaMate

Chemical Property of benzyl5-forMyl-2,2-diMethyl-1,3-dioxan-5-ylcarbaMate

Chemical Property:

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzyl5-forMyl-2,2-diMethyl-1,3-dioxan-5-ylcarbaMate

There total 2 articles about benzyl5-forMyl-2,2-diMethyl-1,3-dioxan-5-ylcarbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol (420107-80-8) → 5-benzyloxycarbonylamino-2,2-dimethyl-1,3-dioxan-5-carbaldehyde (1313876-83-3)

Guidance literature:

With oxalyl dichloride; triethylamine; In dichloromethane; dimethyl sulfoxide; at -78 - 20 ℃; for 0.666667h;

DOI:10.1002/ejoc.201600241

Reference yield:

(5-amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol p-tosylate → 5-benzyloxycarbonylamino-2,2-dimethyl-1,3-dioxan-5-carbaldehyde (1313876-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 1,4-dioxane / 24 h / 20 °C

2: oxalyl dichloride; triethylamine / dimethyl sulfoxide; dichloromethane / 0.67 h / -78 - 20 °C

With oxalyl dichloride; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; dichloromethane; dimethyl sulfoxide;

DOI:10.1002/ejoc.201600241

Reference yield: 95.0%

5-benzyloxycarbonylamino-2,2-dimethyl-1,3-dioxan-5-carbaldehyde (1313876-83-3) → N-α-(benzyloxycarbonyl)-O,O-isopropylidine-α-hydroxymethylserine

Guidance literature:

With sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; In water; tert-butyl alcohol; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201600241

upstream raw materials:

(5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol

Downstream raw materials:

2,2-dimethyl-5-[2-(4-octylphenyl)ethyl]-1,3-dioxan-5-amine

5-(N-Cbz-amino)-5-[2-(4-octyloxyphenyl)ethenyl]-2,2-dimethyl-1,3-dioxane