(5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol

Base Information

• Chemical Name: (5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol
• CAS No.: 420107-80-8
• Molecular Formula: C₁₅H₂₁NO₅
• Molecular Weight: 295.335
• Mol file: 420107-80-8.mol

Synonyms:(5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol

Chemical Property of (5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol

There total 3 articles about (5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(5-amino-2,2-dimethyl-1,3-dioxan-5-yl)methanol p-tosylate + benzyl chloroformate (501-53-1,94274-21-2) → (5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol (420107-80-8)

Guidance literature:

With sodium hydrogencarbonate; In 1,4-dioxane; at 20 ℃; for 24h;

DOI:10.1002/ejoc.201600241

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol (420107-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NaOH / acetonitrile / 12 h / 0 °C

2: 95 percent / TsOH / CH₂Cl₂ / 0.25 h

With sodium hydroxide; toluene-4-sulfonic acid; In dichloromethane; acetonitrile;

DOI:10.1016/S0040-4039(00)60523-3

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → (5-benzyloxycarbonylamino-2,2-dimethyl[1,3]dioxan-5-yl)methanol (420107-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH / acetonitrile; H₂O

2: APTS / CH₂Cl₂

With sodium hydroxide; 8-aminopyrene-1,3,6-trisulfonic acid, trisodium salt; In dichloromethane; water; acetonitrile;

DOI:10.1039/b104958p

upstream raw materials:

benzyl chloroformate

Downstream raw materials:

5-N-(benzyloxycarbonyl)amino-5-N'-1H,1H,2H,2H-perfluorodecylcarbamoyloxymethyl-2,2-dimethyl-1,3-dioxane

5-[O-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)oxymethyl]-5-N-(1,4-pyrazine-2-carboximido)-2,2-dimethyl-1,3-dioxane

5-[O-(2',3',4',6'-tetra-O-acetyl-β-D-galactopyranosyl)oxymethyl]-5-{N-[(4-methylthiobenzyl)carboximido]}-2,2-dimethyl-1,3-dioxane