Technology Process of (8E,10R,12Z)-10-Hydroxy-8,12-octadecadienoic acid methyl ester
There total 8 articles about (8E,10R,12Z)-10-Hydroxy-8,12-octadecadienoic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 0 ℃;
for 7h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 61 percent / LiCl, iso-Pr2NEt / acetonitrile / 43 h / Ambient temperature
2: Zn(BH4)2 / diethyl ether / 4 h / -20 °C
3: 89 percent / Bu4NF / tetrahydrofuran; diethyl ether / 3 h / 0 °C
4: 52 percent / NaIO4 / H2O; acetone / 2 h / Ambient temperature
5: poly-4-vinylpyridine, HMPA / CH2Cl2
6: BuLi / diethyl ether; hexane / 0.67 h / -78 °C
7: 92 percent / Bu4NF / tetrahydrofuran / 7 h / 0 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; sodium periodate; n-butyllithium; zinc(II) tetrahydroborate; poly-4-vinylpyridine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; lithium chloride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetone; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: poly-4-vinylpyridine, HMPA / CH2Cl2
2: BuLi / diethyl ether; hexane / 0.67 h / -78 °C
3: 92 percent / Bu4NF / tetrahydrofuran / 7 h / 0 °C
With
N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; poly-4-vinylpyridine; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane;
