3-(4-Aminophenyl)-N-methylbenzamide

Base Information

• Chemical Name: 3-(4-Aminophenyl)-N-methylbenzamide
• CAS No.: 1335041-46-7
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Hs Code.: 2924299090
• Mol file: 1335041-46-7.mol

Synonyms:3-(4-Aminophenyl)-N-methylbenzamide;4'-AMino-N-Methyl-[1,1'-biphenyl]-3-carboxaMide

Chemical Property of 3-(4-Aminophenyl)-N-methylbenzamide

Chemical Property:

• PSA: 58.61000
• LogP: 3.45140

Purity/Quality:

95+% ^*data from raw suppliers

3-(4-Aminophenyl)-N-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(4-Aminophenyl)-N-methylbenzamide

There total 5 articles about 3-(4-Aminophenyl)-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

C14H12N2O3 (1598408-84-4) → C14H14N2O (1335041-46-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In tetrahydrofuran; for 6h;

DOI:10.1016/j.ejmech.2014.03.020

Reference yield:

3-(4-nitro-phenyl)-benzoyl chloride → C14H14N2O (1335041-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 8 h / 0 - 20 °C

2: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran / 6 h

With 5%-palladium/activated carbon; hydrogen; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.ejmech.2014.03.020

Reference yield:

para-nitrophenyl bromide (586-78-7) → C14H14N2O (1335041-46-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 48 h / Reflux; Inert atmosphere

2: thionyl chloride / 2 h / 0 °C / Reflux

3: triethylamine / dichloromethane / 8 h / 0 - 20 °C

4: hydrogen; 5%-palladium/activated carbon / tetrahydrofuran / 6 h

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; 5%-palladium/activated carbon; hydrogen; potassium carbonate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; water; toluene; 1: |Suzuki Coupling;

DOI:10.1016/j.ejmech.2014.03.020

upstream raw materials:

C₁₄H₁₂N₂O₃

para-nitrophenyl bromide

3-Carboxyphenylboronic acid

4'-nitrobiphenyl-3-carboxylic acid

Downstream raw materials:

1-(4-(3-(Methylcarbamoyl)phenyl)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Refernces