1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

Base Information

• Chemical Name: 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea
• CAS No.: 1342276-76-9
• Molecular Formula: C17H16N4O2S
• Molecular Weight: 340.406
• Mol file: 1342276-76-9.mol

Synonyms:1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea;RKI-1313;RKI-1313 (Negative control of RKI-1447)

Chemical Property of 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

Chemical Property:

• PKA: 6.38±0.70(Predicted)
• PSA: 104.38000
• Density: 1.323±0.06 g/cm3(Predicted)
• LogP: 3.99930

Purity/Quality:

97% ^*data from raw suppliers

1-(3-METHOXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: RKI-1313 is an inhibitor of Rho-associated kinase 1 (ROCK1) and 2 (IC50s = 34 and 8 μM, respectively). It has been used as a negative control for the ROCK inhibitor RKI-1447 .

Technology Process of 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

There total 4 articles about 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

3-METHOXYBENZYLAMINE (5071-96-5) + phenyl 4-(pyridin-4-yl)thiazol-2-ylcarbamate (1342277-18-2) → 1-(3-methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea (1342276-76-9)

Guidance literature:

In tetrahydrofuran; at 100 ℃; for 0.366667h; under 11377.6 Torr; CEM microwave;

Reference yield: 52.0%

4-pyridin-4-yl-thiazol-2-ylamine (30235-28-0) + 1-(isocyanatomethyl)-3-methoxybenzene (57198-56-8) → 1-(3-methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea (1342276-76-9)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; at 150 ℃; for 0.333333h; Biotage microwave;

Reference yield:

4-bromoacetylpyridine hydrobromide (5349-17-7) → 1-(3-methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea (1342276-76-9)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / 0.5 h / 100 °C / Biotage microwave

2: 1-methyl-pyrrolidin-2-one / 0.33 h / 150 °C / Biotage microwave

In 1-methyl-pyrrolidin-2-one; ethanol;

upstream raw materials:

3-METHOXYBENZYLAMINE

phenyl 4-(pyridin-4-yl)thiazol-2-ylcarbamate

4-bromoacetylpyridine hydrobromide

4-pyridin-4-yl-thiazol-2-ylamine

Downstream raw materials:

1-(3-methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

1-(3-methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea methanesulfonate

1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1342276-76-9 1-(3-Methoxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

Send

Send

Metric Ton KG G Pound L ML

Send

Send