1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

Base Information

Chemical Name:1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride
CAS No.:1342278-94-7
Molecular Formula:C₁₆H₁₄N₄O₂S*ClH
Molecular Weight:362.84
Hs Code.:

Synonyms:1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

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Chemical Property of 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

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Technology Process of 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

There total 5 articles about 1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1342278-01-6
1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea

: 1342278-94-7
1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; acetone; at 80 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 5349-17-7
4-bromoacetylpyridine hydrobromide

: 1342278-94-7
1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: ethanol / 0.5 h / 100 °C / Microwave irradiation

2: pyridine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran; acetonitrile / 0.33 h / 100 °C / 11377.6 Torr / Microwave irradiation; Autoclave

4: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Autoclave

5: hydrogenchloride / acetone; 1,4-dioxane / 0.33 h / Inert atmosphere; Heating

With pyridine; hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetone; acetonitrile;
DOI:10.1039/c2md00320a

Reference yield:

: 1342277-18-2
phenyl 4-(pyridin-4-yl)thiazol-2-ylcarbamate

: 1342278-94-7
1-(3-hydroxybenzyl)-3-(4-(pyridin-4-yl)thiazol-2-yl)urea hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran; acetonitrile / 0.33 h / 100 °C / 11377.6 Torr / Microwave irradiation; Autoclave

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere; Autoclave

3: hydrogenchloride / acetone; 1,4-dioxane / 0.33 h / Inert atmosphere; Heating

With hydrogenchloride; triethylamine; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetone; acetonitrile;
DOI:10.1039/c2md00320a