2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid

Base Information

• Chemical Name: 2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid
• CAS No.: 749230-42-0
• Molecular Formula: C7H3ClF2O3
• Molecular Weight: 208.549
• Hs Code.: 2918290000
• Mol file: 749230-42-0.mol

Synonyms:2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid;2-Chloro-3,6-difluoro-4-hydroxybenzoic acid

Chemical Property of 2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid

Chemical Property:

• PSA: 57.53000
• LogP: 2.02200

Purity/Quality:

98%min ^*data from raw suppliers

2-Chloro-3,6-difluoro-4-hydroxybenzoic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid

There total 3 articles about 2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

carbon dioxide (124-38-9,18923-20-1) + [4-chloro-3,6-difluoro-2-(methoxymethoxy)phenyl]trimethylsilane (749230-41-9) → 2-chloro-3,6-difluoro-4-hydroxybenzoic acid (749230-42-0)

Guidance literature:

[4-chloro-3,6-difluoro-2-(methoxymethoxy)phenyl]trimethylsilane; With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

carbon dioxide; In tetrahydrofuran; hexane;

With hydrogenchloride; pH=1;

DOI:10.1055/s-2004-829110

Reference yield:

2,5-difluorophenol (2713-31-7) → 2-chloro-3,6-difluoro-4-hydroxybenzoic acid (749230-42-0)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 91 percent / N-ethyldiisopropylamine / CH₂Cl₂ / 2 h / 25 °C

2.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C

2.2: 84 percent / tetrahydrofuran; hexane / 0.75 h / -75 °C

3.1: sec-BuLi; N,N,N',N'',N''-pentamethylethylenetriamine / tetrahydrofuran; cyclohexane / 2 h / -75 °C

3.2: 64 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; cyclohexane

4.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C

4.2: tetrahydrofuran; hexane

4.3: 65 percent / aq. HCl / pH 1

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; N,N,N',N'',N''-pentamethylethylenetriamine; sec.-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; dichloromethane; cyclohexane;

DOI:10.1055/s-2004-829110

Reference yield:

1,4-difluoro-2-(methoxymethoxy)benzene (749230-16-8) → 2-chloro-3,6-difluoro-4-hydroxybenzoic acid (749230-42-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: BuLi / tetrahydrofuran; hexane / 2 h / -75 °C

1.2: 84 percent / tetrahydrofuran; hexane / 0.75 h / -75 °C

2.1: sec-BuLi; N,N,N',N'',N''-pentamethylethylenetriamine / tetrahydrofuran; cyclohexane / 2 h / -75 °C

2.2: 64 percent / 1,1,2-trichloro-1,2,2-trifluoroethane / tetrahydrofuran; cyclohexane

3.1: BuLi; 2,2,6,6-tetramethylpiperidine / tetrahydrofuran; hexane / 2 h / -75 °C

3.2: tetrahydrofuran; hexane

3.3: 65 percent / aq. HCl / pH 1

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; N,N,N',N'',N''-pentamethylethylenetriamine; sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane;

DOI:10.1055/s-2004-829110

upstream raw materials:

carbon dioxide

[4-chloro-3,6-difluoro-2-(methoxymethoxy)phenyl]trimethylsilane

2,5-difluorophenol

1,4-difluoro-2-(methoxymethoxy)benzene

Downstream raw materials:

2,5-difluoro-4-hydroxybenzoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 749230-42-0 2-Chloro-3,6-difluoro-4-hydroxybenzenecarboxylic acid

Send

Send

Metric Ton KG G Pound L ML

Send

Send