Benzyl (4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-yl)carbaMate

Base Information

• Chemical Name: Benzyl (4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-yl)carbaMate
• CAS No.: 864063-55-8
• Molecular Formula: C17H23NO3
• Molecular Weight: 289.375
• Hs Code.: 2924299090
• Mol file: 864063-55-8.mol

Synonyms:Benzyl (4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-yl)carbaMate;Carbamic acid, [4-(hydroxymethyl)bicyclo[2.2.2]oct-1-yl]-, phenylmethyl ester (9CI)

Chemical Property of Benzyl (4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-yl)carbaMate

Chemical Property:

• PSA: 62.05000
• LogP: 3.20250
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

Benzyl(4-(hydroxymethyl)bicyclo[2.2.2]octan-1-yl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzyl (4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-yl)carbaMate

There total 1 articles about Benzyl (4-(hydroxyMethyl)bicyclo[2.2.2]octan-1-yl)carbaMate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[[(benzyloxy)carbonyl]amino]-bicyclo[2.2.2]octane-1-carboxylic acid (444344-91-6) → benzyl (4-(hydroxymethyl)bicyclo[2.2,2]octan-1-yl)carbamate (864063-55-8)

Guidance literature:

4-[[(benzyloxy)carbonyl]amino]-bicyclo[2.2.2]octane-1-carboxylic acid; With 4-methyl-morpholine; chloroformic acid ethyl ester; In tetrahydrofuran; at 0 ℃; for 0.166667h;

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 0 ℃; for 1h;

Reference yield:

benzyl (4-(hydroxymethyl)bicyclo[2.2,2]octan-1-yl)carbamate (864063-55-8) → benzyl (4-formylbicyclo[2,2.2]octan-1-yl)carbamate (1093231-02-7)

Guidance literature:

With Dess-Martin periodane; In dichloromethane;

Reference yield:

benzyl (4-(hydroxymethyl)bicyclo[2.2,2]octan-1-yl)carbamate (864063-55-8) → 4-(difluoromethyl)bicyclo[2.2.2]octan-1-amine (1245643-16-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridinium chlorochromate / dichloromethane / 2 h / 0 - 20 °C

2: diethylamino-sulfur trifluoride / dichloromethane / 2 h / 0 - 20 °C

3: palladium 10% on activated carbon; hydrogen / dichloromethane / 16 h / 20 °C / 760.05 Torr

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; pyridinium chlorochromate; In dichloromethane;

upstream raw materials:

4-[[(benzyloxy)carbonyl]amino]-bicyclo[2.2.2]octane-1-carboxylic acid

Downstream raw materials:

benzyl (4-formylbicyclo[2,2.2]octan-1-yl)carbamate

4-(difluoromethyl)bicyclo[2.2.2]octan-1-amine