1245643-16-6

Upstream product

• 1093231-02-7 benzyl (4-formylbicyclo[2,2.2]octan-1-yl)carbamate 
• 864063-55-8 benzyl (4-(hydroxymethyl)bicyclo[2.2,2]octan-1-yl)carbamate 
• 444344-91-6 4-[[(benzyloxy)carbonyl]amino]-bicyclo[2.2.2]octane-1-carboxylic acid 
• 862501-91-5 methyl 4-(((benzyloxy)carbonyl)amino)bicyclo[2.2.2]octane-1-carboxylate 
• 18720-35-9 bicyclo[2.2.2]octane-1,4-dicarboxylic acid monomethyl ester 
• 1252672-41-5 benzyl (4-(difluoromethyl)bicycio[2.2,2]octan-1-yl)carbamate 

Downstream Products

• 1252787-43-1 2-(4-chlorophenoxy)-N'-cyano-N-[4-(difluoromethyl)bicyclo[2.2.2]oct-1-yl]-2-methylpropanimidamide 

Relevant academic research and scientific papers

CYANO-PYRIMIDINE INHIBITORS OF EGFR/HER2

Provided herein are compounds, pharmaceutical compositions comprising such compounds, and methods of using such compounds to treat diseases or disorders associated with EGFR and/or HER2 activity.

NOVEL AMIDE AND AMIDINE DERIVATIVES AND USES THEREOF

The present invention relates to inhibitors of 11-β-hydroxysteroid dehydrogenase type 1 enzyme and their use in treatment of non-insulin dependent type 2 diabetes, insulin resistance, obesity, lipid disorders, metabolic syndrome, central nervous system disorders, and diseases and conditions that are related to excessive glucocorticoids.

CARBOXYLIC ACID-CONTAINING COMPOUNDS, DERIVATIVES THEREOF, AND RELATED METHODS OF USE

Compounds that modulate gamma secretase (e.g., alter the cleavage pattern of gamma secretase) are described herein. Also disclosed are pharmaceutical compositions, methods of modulating the activity of gamma secretase, and methods of treating Alzheimer's Disease using the compounds described herein.