3'-N-DesMethyl-3'-N-tosyl AzithroMycin

Base Information

• Chemical Name: 3'-N-DesMethyl-3'-N-tosyl AzithroMycin
• CAS No.: 612069-31-5
• Molecular Formula: C44H76N2O14S
• Molecular Weight: 889.14424
• Mol file: 612069-31-5.mol

Synonyms:3'-N-DesMethyl-3'-N-tosyl AzithroMycin;(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-Methyl-3-O-Methyl -α-L-ribo-hexopyranosyl)oxy]-2-ethyl-3,4,10-trihydroxy-3,5,6,8,10,12,14-heptaMethyl-11-[[3,4,6-trideoxy-3-[Methyl[(4-Methylphenyl)sulfonyl]aMino]-β-D-xylo-hexopyranosyl]oxy]-1-oxa-6-azacyclopentadecan-15-one;3'-N-Demethyl-3'-N-((4-methylphenyl)sulfonyl)azithromycin;Azithromycin EP Impurity G

Chemical Property of 3'-N-DesMethyl-3'-N-tosyl AzithroMycin

Chemical Property:

• Boiling Point: 930.7±75.0 °C(Predicted)
• PKA: 13.14±0.70(Predicted)
• PSA: 222.60000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 3.98690
• Storage Temp.: -20°C Freezer
• Solubility.: Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

NLT 98% ^*data from raw suppliers

3’-N-Desmethyl-3’-N-tosylAzithromycin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: 3’-N-Desmethyl-3’-N-tosyl Azithromycin (Azithromycin EP Impurity G) is an Azithromycin (A927000) impurity. Azithromycin (A927000) impurity.

Technology Process of 3'-N-DesMethyl-3'-N-tosyl AzithroMycin

There total 1 articles about 3'-N-DesMethyl-3'-N-tosyl AzithroMycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)‐2‐ethyl‐3,4,10‐trihydroxy‐13‐{(2R,4R,5S,6S)‐5‐hydroxy‐4‐methoxy‐4,6‐dimethyl-tetrahydropyran‐2‐yloxy}‐11‐{(2S,3R,4S,6R)‐3‐hydroxy‐6‐methyl‐4‐methylamino-tetrahydropyran‐2‐yloxy}‐3,5,6,8,10,12,14‐heptamethyl‐1‐oxa‐6‐azacyclopentadecan‐15‐one (172617-84-4) + p-toluenesulfonyl chloride (98-59-9) → N-[(2S,3R,4S,6R)-2-[[(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydropyran-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-15-oxo-1-oxa-6-azacyclopentadec-11-yl]oxy]-3-hydroxy-6-methyltetrahydropyran-4-yl]-N,4-dimethylbenzenesulfonamide (612069-31-5)

Guidance literature:

With sodium hydrogencarbonate; In isopropyl alcohol;

upstream raw materials:

(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)‐2‐ethyl‐3,4,10‐trihydroxy‐13‐{(2R,4R,5S,6S)‐5‐hydroxy‐4‐methoxy‐4,6‐dimethyl-tetrahydropyran‐2‐yloxy}‐11‐{(2S,3R,4S,6R)‐3‐hydroxy‐6‐methyl‐4‐methylamino-tetrahydropyran‐2‐yloxy}‐3,5,6,8,10,12,14‐heptamethyl‐1‐oxa‐6‐azacyclopentadecan‐15‐one

p-toluenesulfonyl chloride

Refernces