7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-

Base Information

• Chemical Name: 7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-
• CAS No.: 476474-11-0
• Molecular Formula: C20H16N4O
• Molecular Weight: 328.373
• Hs Code.: 2933990090
• Mol file: 476474-11-0.mol

Synonyms:7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-;F9995-0144;4-(2-(pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ol

Chemical Property of 7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-

Chemical Property:

• Boiling Point: 557.3±50.0 °C(Predicted)
• PKA: 8.53±0.40(Predicted)
• PSA: 63.83000
• Density: 1.40±0.1 g/cm3(Predicted)
• LogP: 3.81210

Purity/Quality:

99% ^*data from raw suppliers

4-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(2-(Pyridin-2-yl)-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ol is a casein kinase 1δ inhibitor that can be used in the treatment of neurodegenerative disorders

Technology Process of 7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-

There total 1 articles about 7-Quinolinol, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

7-methoxy-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline (476474-40-5) → 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ol (476474-11-0)

Guidance literature:

With hydrogen bromide; at 110 ℃; for 24h;

DOI:10.1021/jm701199p

Reference yield: 95.0%

4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ol (476474-11-0) + 4-fluorobenzonitrile (1194-02-1,143234-87-1) → C27H19N5O (1018353-32-6) + C27H21N5O2 (1018353-35-9)

Guidance literature:

With 18-crown-6 ether; In dimethyl sulfoxide; at 140 ℃;

DOI:10.1021/jm701199p

Reference yield: 81.0%

2-(2-bromoethoxy)tetrahydropyran (17739-45-6,59146-56-4) + 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinolin-7-ol (476474-11-0) → 4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-7-[2-(tetrahydropyran-2-yloxy)ethoxy]quinoline (700874-73-3)

Guidance literature:

With caesium carbonate; In DMF (N,N-dimethyl-formamide); at 120 ℃; for 4h;

upstream raw materials:

7-methoxy-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)quinoline

Downstream raw materials:

4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-3-yl)-7-[2-(tetrahydropyran-2-yloxy)ethoxy]quinoline

C₂₇H₁₉N₅O

C₂₇H₂₁N₅O₂

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