476474-40-5 Usage
Uses
Used in Medicinal Chemistry:
Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-Methoxyis used as a compound in medicinal chemistry for its potential biological and pharmacological properties. Its unique structure may contribute to the development of new drugs and therapeutic agents.
Used in Drug Development:
In the field of drug development, Quinoline, 4-[5,6-dihydro-2-(2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-7-Methoxyis utilized for its potential to be incorporated into new pharmaceuticals. Further research is necessary to explore its specific characteristics and applications in creating effective treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 476474-40-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,6,4,7 and 4 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 476474-40:
(8*4)+(7*7)+(6*6)+(5*4)+(4*7)+(3*4)+(2*4)+(1*0)=185
185 % 10 = 5
So 476474-40-5 is a valid CAS Registry Number.
476474-40-5Relevant academic research and scientific papers
Optimization of a dihydropyrrolopyrazole series of transforming growth factor-β type I receptor kinase domain inhibitors: Discovery of an orally bioavailable transforming growth factor-β receptor type I inhibitor as antitumor agent
Li, Hong-Yu,McMillen, William T.,Heap, Charles R.,McCann, Denis J.,Yan, Lei,Campbell, Robert M.,Mundla, Sreenivasa R.,King, Chi-Hsin R.,Dierks, Elizabeth A.,Anderson, Bryan D.,Britt, Karen S.,Huss, Karen L.,Voss, Matthew D.,Wang, Yan,Clawson, David K.,Yingling, Jonathan M.,Sawyer, J. Scott
, p. 2302 - 2306 (2008/12/20)
In our continuing effort to expand the SAR of the quinoline domain of dihydropyrrolopyrazole series, we have discovered compound 15d, which demonstrated the antitumor efficacy with oral bioavailability. This effort also demonstrated that the PK/PD in vivo target inhibition paradigm is an effective approach to assess potential for antitumor efficacy. The dihydropyrrolopyrazole inhibitor 15d (LY2109761) is representative of a novel series of antitumor agents.
