(3R, 4R)-4-Methyl-3-MethylaMino-piperidine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: (3R, 4R)-4-Methyl-3-MethylaMino-piperidine-1-carboxylic acid tert-butyl ester
• CAS No.: 1312762-44-9
• Molecular Formula: C12H24N2O2
• Molecular Weight: 228.335
• Mol file: 1312762-44-9.mol

Synonyms:(3R,4R)-1-Boc-4-methyl-3-methylamino-piperidine

Chemical Property of (3R, 4R)-4-Methyl-3-MethylaMino-piperidine-1-carboxylic acid tert-butyl ester

Chemical Property:

• Boiling Point: 299.6±33.0 °C(Predicted)
• PKA: 10.12±0.40(Predicted)
• PSA: 41.57000
• Density: 1.00±0.1 g/cm3(Predicted)
• LogP: 2.18010

Purity/Quality:

98%min ^*data from raw suppliers

(3R,4R)-4-Methyl-3-methylamino-piperidine-1-carboxylicacidtert-butylester 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (3R, 4R)-4-Methyl-3-MethylaMino-piperidine-1-carboxylic acid tert-butyl ester

There total 17 articles about (3R, 4R)-4-Methyl-3-MethylaMino-piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester (1312762-43-8) → (3R,4R)-3-methylamino-4-methylpiperidine-1-carboxylic acid tert-butyl ester (1312762-44-9,344419-25-6)

Guidance literature:

With 5% Pd(II)/C(eggshell); ammonium formate; In methanol; for 5h; Reflux;

DOI:10.1055/s-0030-1259963

Reference yield: 92.3%

(3R,4R)-1-tert-butoxycarbonyl-3-[(S)-N-methyl-1-phenylethylamino]-4-methylpiperidine L-(-)-tartrate → (3R,4R)-3-methylamino-4-methylpiperidine-1-carboxylic acid tert-butyl ester (1312762-44-9,344419-25-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In ethanol;

Reference yield: 87.8%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (3R,4R)-3-amino-4-methylpiperidine-1-carboxylic acid tert-butyl ester (1207853-61-9,1271810-27-5,1312810-20-0,1434126-96-1,1792190-70-5) → (3R,4R)-3-methylamino-4-methylpiperidine-1-carboxylic acid tert-butyl ester (1312762-44-9,344419-25-6)

Guidance literature:

formaldehyd; (3R,4R)-3-amino-4-methylpiperidine-1-carboxylic acid tert-butyl ester; With sodium methylate; In methanol; at 20 ℃; for 24h;

With methanol; sodium tetrahydroborate; at 40 ℃; for 3h;

upstream raw materials:

5-[(1R)-1-phenyl-ethylamino]-3,6-dihydro-2H-pyridine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

ethyl (3R,4R)-1-(tert-butoxycarbonyl)-3-{[(1R)-1-phenylethyl]amino}piperidine-4-carboxylate

(3R,4R)-1-(tert-butoxycarbonyl)-4-hydroxymethyl-3-{methyl[(1R)-1-phenylethyl]amino}piperidine

(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-D]pyrimidin-4-amine hydrochloride

Refernces

• 1、 -. "A method for synthesis of piperidine derivatives (by machine translation)". . . Retrieved 2018/10/19.
• 2、 Hao, Bao-Yu,Liu, Jin-Qiang,Zhang, Wei-Han,Chen, Xin-Zhi. "A novel asymmetric synthesis of cis-(3R,4R)-N-(tert -butoxycarbonyl)-4- methyl-3-(methylamino)piperidine". . p. 1208 - 1212. Retrieved 2011/05/30.