(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester
CAS No.:1312762-43-8
Molecular Formula:C₂₀H₃₂N₂O₂
Molecular Weight:332.486
Hs Code.:

Synonyms:(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

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Technology Process of (3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

There total 13 articles about (3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1312762-42-7
(3R,4R)-4-(acetylthiomethyl)-1-(tert-butoxycarbonyl)-3-{methyl[(1R)-1-phenylethyl]amino}piperidine

: 1312762-43-8
(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With hydrogen; In ethanol; at 20 ℃; for 4h;
DOI:10.1055/s-0030-1259963

Reference yield: 86.2%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: (3R,4R)-4-methyl-3-(((1R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

: 1312762-43-8
(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With sodium tetrahydroborate; acetic acid; In water; 1,2-dichloro-ethane; at 20 ℃; for 2h;

Reference yield:

: 388108-70-1
ethyl (3R,4R)-1-(tert-butoxycarbonyl)-3-{[(1R)-1-phenylethyl]amino}piperidine-4-carboxylate

: 1312762-43-8
(3R,4R)-4-methyl-3-(methyl-((R)-1-phenylethyl)amino)piperidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloromethane / 1.5 h / 20 °C / Inert atmosphere

1.2: 20 °C / Inert atmosphere; Cooling with ice

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / Inert atmosphere; Cooling with ice

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / Inert atmosphere; Cooling with ice; Reflux

3.2: 0.5 h / Inert atmosphere

4.1: hydrogen / ethanol / 4 h / 20 °C

With lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; hydrogen; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; 3.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;
DOI:10.1055/s-0030-1259963