1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine

Base Information

Chemical Name:1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine
CAS No.:876717-03-2
Molecular Formula:C13H18N2O
Molecular Weight:218.299
Hs Code.:2934999090
DSSTox Substance ID:DTXSID50390221
ChEMBL ID:CHEMBL1334385
Mol file:876717-03-2.mol

Synonyms:1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine;876717-03-2;1-(2,3-dihydro-1-benzofuran-2-ylmethyl)piperazine;1-((2,3-Dihydrobenzofuran-2-yl)methyl)piperazine;MLS001206932;CHEMBL1334385;SCHEMBL15708109;DTXSID50390221;DNZIVLPHTKLWQR-UHFFFAOYSA-N;HMS1698O02;HMS2816H18;BBL030659;STK587015;AKOS000302953;AKOS017466397;SMR000524686;VS-09958;FT-0741826;1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine;1-[(2,3-dihydro-1-benzofuran-2yl)methyl]piperazine;Z969132108

Suppliers and Price of 1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine
1g
$ 400.00

Crysdot
1-((2,3-Dihydrobenzofuran-2-yl)methyl)piperazine 97%
5g
$ 874.00

American Custom Chemicals Corporation
1-(2,3-DIHYDRO-BENZOFURAN-2-YLMETHYL)-PIPERAZINE 95.00%
500MG
$ 777.32

AK Scientific
1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine
1g
$ 590.00

Total 2 raw suppliers

Chemical Property of 1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine

Chemical Property:

PSA：24.50000
LogP:1.16200
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:218.141913202
Heavy Atom Count:16
Complexity:228

Purity/Quality:

98%min ^*data from raw suppliers

1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CN(CCN1)CC2CC3=CC=CC=C3O2

Technology Process of 1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine

There total 4 articles about 1-(2,3-Dihydro-benzofuran-2-ylmethyl)-piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 110-85-0
piperazine

: 59152-49-7
2-(iodomethyl)-2,3-dihydro-1-benzofuran

: 876717-03-2
1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine

Guidance literature:: With base; In tetrahydrofuran; Reflux;
DOI:10.1111/cbdd.12947

Reference yield:

: 1745-81-9
o-Allylphenol

: 876717-03-2
1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine

Guidance literature:: Multi-step reaction with 2 steps

1: tin(IV) chloride; iodine / dichloromethane / 5.5 h / 20 °C

2: potassium carbonate / acetonitrile / 2 h / Reflux

With iodine; tin(IV) chloride; potassium carbonate; In dichloromethane; acetonitrile;

Reference yield:

: 1746-13-0
allyl phenyl ether

: 876717-03-2
1-[(2,3-dihydro-1-benzofuran-2-yl)methyl]piperazine

Guidance literature:: Multi-step reaction with 3 steps

1: boron trichloride / dichloromethane / 0.5 h / -30 - -20 °C / Inert atmosphere

2: tin(IV) chloride; iodine / dichloromethane / 5.5 h / 20 °C

3: potassium carbonate / acetonitrile / 2 h / Reflux

With iodine; boron trichloride; tin(IV) chloride; potassium carbonate; In dichloromethane; acetonitrile;