Technology Process of 2,2-dimethylhex-4-yn-1-ol
There total 1 articles about 2,2-dimethylhex-4-yn-1-ol which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
diisobutylaluminium hydride;
In
toluene;
at -10 ℃;
DOI:10.1021/jo2011494
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: potassium tert-butylate; n-hexyllithium; Trimethylenediamine
2.1: N,N-dimethyl-formamide / 20 °C
2.2: 12 h / 90 °C
With
potassium tert-butylate; n-hexyllithium; Trimethylenediamine;
In
N,N-dimethyl-formamide;
DOI:10.1021/jo2011494
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: triethylamine; sulfur trioxide pyridine complex / dichloromethane; dimethyl sulfoxide / 1.75 h / 0 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C / Inert atmosphere; Molecular sieve
3.1: Dess-Martin periodane / dichloromethane / 0 °C / Inert atmosphere
4.1: chloro(1,5-cyclooctadiene)rhodium(I) dimer / 1,4-dioxane / 0.17 h / 20 °C / Inert atmosphere
4.2: 20 h / 20 °C / Inert atmosphere
With
chloro(1,5-cyclooctadiene)rhodium(I) dimer; tetrabutyl ammonium fluoride; sulfur trioxide pyridine complex; Dess-Martin periodane; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide;
DOI:10.1002/chem.201404896