Benzyl4-(4-bromophenyl)piperazine-1-carboxylate

Base Information

• Chemical Name: Benzyl4-(4-bromophenyl)piperazine-1-carboxylate
• CAS No.: 1150271-33-2
• Molecular Formula: C18H19BrN2O2
• Molecular Weight: 375.265
• Hs Code.: 2933599090
• Mol file: 1150271-33-2.mol

Synonyms:Benzyl4-(4-bromophenyl)piperazine-1-carboxylate

Chemical Property of Benzyl4-(4-bromophenyl)piperazine-1-carboxylate

Chemical Property:

• PSA: 32.78000
• LogP: 3.91080
• Storage Temp.: 2-8°C

Purity/Quality:

95% ^*data from raw suppliers

Benzyl4-(4-Bromophenyl)piperazine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzyl4-(4-bromophenyl)piperazine-1-carboxylate

There total 2 articles about Benzyl4-(4-bromophenyl)piperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl 4-phenylpiperazine-1-carboxylate (104055-49-4) → 4-(4-bromophenyl)piperazine-1-carboxylic acid benzyl ester (1150271-33-2)

Guidance literature:

With N-Bromosuccinimide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

1-(4-bromophenyl)piperazine (66698-28-0) + benzyl chloroformate (501-53-1,94274-21-2) → 4-(4-bromophenyl)piperazine-1-carboxylic acid benzyl ester (1150271-33-2)

Guidance literature:

With triethylamine; In benzyl chloroformate; Inert atmosphere; Cooling with ice;

Reference yield:

3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester (887590-25-2) + 4-(4-bromophenyl)piperazine-1-carboxylic acid benzyl ester (1150271-33-2) → 4-[4-(4-(benzyloxycarbonyl)piperazin-1-yl)phenyl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester (1187522-66-2)

Guidance literature:

With sodium t-butanolate; tri-tert-butyl phosphine; palladium diacetate; In o-xylene; at 150 ℃; for 18h; Inert atmosphere;

upstream raw materials:

1-(4-bromophenyl)piperazine

benzyl chloroformate

benzyl 4-phenylpiperazine-1-carboxylate

Downstream raw materials:

4-[4-(4-(benzyloxycarbonyl)piperazin-1-yl)phenyl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester

Refernces

• 1、 -. "TETRAHYDROQUINOXALINE UREA DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION". Page/Page column 32. . Retrieved 2011/02/15.