887590-25-2

Usage

Uses

Used in Pharmaceutical Industry:
3,4-Dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 3,4-Dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester serves as a key intermediate in the production of various agrochemicals. Its role in the synthesis of these compounds contributes to the development of effective pesticides and other agricultural chemicals that help protect crops and enhance agricultural productivity.

InChI:InChI=1/C13H18N2O2/c1-13(2,3)17-12(16)15-9-8-14-10-6-4-5-7-11(10)15/h4-7,14H,8-9H2,1-3H3

Upstream product

• 3476-89-9 1,2,3,4-tetrahydroquinoxaline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 459817-82-4 2,2-dioxo-[1,2,3]oxathiazolidine-3-carboxylic acid tert-butyl ester 
• 615-36-1 2-bromoaniline 
• 1441005-75-9 C₁₃H₁₉BrN₂O₂ 
• 59564-59-9 1,2,3,4-tetrahydroquinoxalin-2-one 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 1000688-83-4 tert-butyl 4-(4-cyanophenyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate 
• 1304598-85-3 tert-butyl 4-(4-(methoxycarbonyl)benzyl)-3,4-dihydroquinoxaline-1(2H)-carboxylate 
• 1187522-87-7 4-[5-(4-(benzyloxycarbonyl)piperazin-1-yl)pyridin-2-yl]-3,4-dihydro-2H-quinoxaline-1-carboxylic acid tert-butyl ester 
• 1304598-38-6 C₂₀H₂₁N₃O₆ 
• 1304598-63-7 C₁₅H₁₃N₃ 
• 1304598-51-3 C₁₆H₁₅N₃O₄ 
• 1304598-48-8 C₁₅H₁₃N₃O₄ 
• 1304599-06-1 C₂₇H₂₇N₇O₂ 
• 1304599-02-7 C₁₉H₁₈N₄O 
• 1000688-56-1 N-Cyclopropyl-4-{4-[3-(1H-pyrazol-4-yl)pyrrolidine-1-carbonyl]-3,4-dihydro-2H-quinoxalin-1-ylmethyl}benzamide 
• 1000688-43-6 4-{4-[3-(1H-Pyrazol-4-yl)pyrrolidine-1-carbonyl]-3,4-dihydro-2H-quinoxalin-1-ylmethyl}benzoic acid 
• 1000688-20-9 4-{4-[3-(1H-Pyrazol-4-yl)pyrrolidine-1-carbonyl]-3,4-dihydro-2H-quinoxalin-1-ylmethyl}benzoic acid methyl ester 
• 1000687-52-4 N-Cyclopropyl-4-{4-[3-(1H-pyrazol-4-yl)pyrrolidine-1-carbonyl]-3,4-dihydro-2H-quinoxalin-1-yl}benzamide 

Relevant academic research and scientific papers

TETRAHYDROQUINOLINE SUBSTITUTED HYDROXAMIC ACIDS AS SELECTIVE HISTONE DEACETYLASE 6 INHIBITORS

Histone deacetylases inhibitors (HDACIs) and compositions containing the same are disclosed. Methods of treating diseases and conditions wherein inhibition of HDAC provides a benefit, like a cancer, a neurodegenerative disorder, a neurological disease, tr

4,5,6,7-TETRAHYDRO-1 H-PYRAZOLO[4,3-C]PYRIDIN-3-AMINE COMPOUNDS AS CBP AND/OR EP300 INHIBITORS

The present invention relates to compounds of formula (I) or formula (II): and to salts thereof, wherein R1-R4 of formula (I) and R1-R3 of formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II) or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

Synthesis of dihydrobenzo[1,4]oxazines using copper catalyzed intramolecular ring closure reaction

The synthesis of dihydrobenzo[1,4]oxazines has been accomplished efficiently by copper catalyzed intramolecular cyclization of the adducts formed by the treatment of 1,2-cyclic sulfamidates with 2-halo phenols. The products (except two) are new and their yields are high. The catalyst is easily available and less expensive.

COMPOUND HAVING 11 ?-HSD1 INHIBITORY ACTIVITY

The present invention provides compounds having excellent 11β-HSD1 inhibitory activity. A compound represented by the following formula (I): [wherein X1 represents an oxygen atom, or the formula -(CR11R12)p-, etc., Y1 represents a hydrogen atom, a hydroxyl group, etc., Z1 represents an oxygen atom or the formula -(NR14)-, R1 represents a hydrogen atom, a halogen atom, a cyano group, a C1-4 alkyl group, a C1-4 alkyl group substituted with 1 to 3 halogen atoms, a C1-4 alkoxy group, a C1-4 alkoxycarbonyl group, a carboxyl group, a carbamoyl group, or an amino group, and m represents an integer of 1 or 2, and R2 represents a hydrogen atom or a C1-4 alkyl group, and n represents an integer of 1 or 2].