2-ethynyl-5-fluorobenzaldehyde

Base Information

• Chemical Name: 2-ethynyl-5-fluorobenzaldehyde
• CAS No.: 1015731-79-9
• Molecular Formula: C9H5FO
• Molecular Weight: 148.137
• Hs Code.: 2913000090
• Mol file: 1015731-79-9.mol

Synonyms:2-ethynyl-5-fluorobenzaldehyde;Benzaldehyde, 2-ethynyl-5-fluoro-;2-Ethynyl-5-fluorobenzaldehyde 97%;4-Fluoro-2-formylphenylacetylene;2-Ethynyl-5-fluorobenzaldehyde97%

Chemical Property of 2-ethynyl-5-fluorobenzaldehyde

Chemical Property:

• PSA: 17.07000
• LogP: 1.61950

Purity/Quality:

97% ^*data from raw suppliers

2-Ethynyl-5-fluorobenzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-ethynyl-5-fluorobenzaldehyde

There total 4 articles about 2-ethynyl-5-fluorobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

5-fluoro-(2-(trimethylsilyl)ethynyl)benzaldehyde → 2-ethynyl-5-fluorobenzaldehyde (1015731-79-9)

Guidance literature:

With methanol; potassium carbonate; at 20 ℃; for 3h;

DOI:10.1002/chem.201002074

Reference yield: 77.0%

2-bromo-5-fluorobenzaldehyde (94569-84-3) + trimethylsilylacetylene (1066-54-2) → 2-ethynyl-5-fluorobenzaldehyde (1015731-79-9)

Guidance literature:

2-bromo-5-fluorobenzaldehyde; trimethylsilylacetylene; With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 80 ℃; Inert atmosphere;

With methanol; potassium carbonate; at 20 ℃; for 0.25h;

DOI:10.1021/jo901090u

Reference yield:

2-bromo-5-fluorobenzaldehyde (94569-84-3) → 2-ethynyl-5-fluorobenzaldehyde (1015731-79-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

1.2: 5 h / 80 °C / Inert atmosphere

2.1: potassium carbonate; methanol / 5 h / 20 °C

With methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium carbonate; triethylamine; In tetrahydrofuran;

DOI:10.1002/cjoc.201201118

upstream raw materials:

2-bromo-5-fluorobenzaldehyde

trimethylsilylacetylene

Downstream raw materials:

13-(2-bromophenyl)-9-fluoro-7,7a-dihydroisoquinolino[2,1-a]perimidine

2-[(2-bromophenyl)ethynyl]-5-fluorobenzaldehyde

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1015731-79-9 2-ethynyl-5-fluorobenzaldehyde

Send

Send

Metric Ton KG G Pound L ML

Send

Send