2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide

Base Information

• Chemical Name: 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide
• CAS No.: 1083326-46-8
• Molecular Formula: C11H18BN3O3
• Molecular Weight: 251.093
• Hs Code.: 2934999090
• Mol file: 1083326-46-8.mol

Synonyms:2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide;4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetamide;2-[4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]acetaMide;1H-Pyrazole-1-acetaMide, 4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-

Chemical Property of 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide

Chemical Property:

• Boiling Point: 440.8±25.0 °C(Predicted)
• PKA: 15?+-.0.40(Predicted)
• PSA: 79.37000
• Density: 1.21±0.1 g/cm3(Predicted)
• LogP: 0.36790
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-acetamide, can be used in the preparation of pharmaceutical and biologically active compounds, including inhibitors and therapeutic agents.

Technology Process of 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide

There total 1 articles about 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

pyrazole-4-boronic acid pinacol ester (269410-08-4) + bromo-acetic acid amide (683-57-8) → 2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide (1083326-46-8)

Guidance literature:

With caesium carbonate; In acetonitrile; at 90 ℃; for 3h;

Reference yield: 68.0%

2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide (1083326-46-8) + tert-butyl (3-bromo-1-((1s,4s)-4-((3-fluoro-4-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)(ethyl)carbamate → tert-butyl (3-(1-(2-amino-2-oxoethyl)-1H-pyrazol-4-yl)-1-((1s,4s)-4-((3-fluoro-4-(trifluoromethyl)pyridin-2-yl)oxy)cyclohexyl)-1H-pyrazolo[4,3-c]pyridin-6-yl)(ethyl)carbamate

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; at 100 ℃;

Reference yield: 60.0%

2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)acetamide (1083326-46-8) + (R)-8-bromo-4-(((tert-butyldimethylsilyl)oxy)methyl)-6-(4-chlorophenyl)-1-methyl-4H-benzo[f][1,2,4]triazolo[4,3-a][1,4]diazepine → (R)-2-(4-(4-(((tert-butyldimethylsilyl)oxy)methyl)-6-(4-chlorophenyl)-1-methyl-4Hbenzo[f][1,2,4]triazolo[4,3-a][1,4]diazepin-8-yl)-1Hpyrazol-1-yl)acetamide

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 20 ℃; for 4h; Inert atmosphere; Reflux;

upstream raw materials:

pyrazole-4-boronic acid pinacol ester

bromo-acetic acid amide

Downstream raw materials:

2-(4-(5-(3-(cyclopentyloxy)-4-methoxybenzylamino)pyridin-3-yl)-1H-pyrazol-1-yl)acetamide

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