683-57-8

Usage

Uses

Used in Pharmaceutical Industry:
2-Bromoacetamide is used as a synthetic intermediate for the preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester, which is a key compound in the development of pharmaceuticals. It plays a crucial role in the synthesis of drugs with potential therapeutic applications.
Used in Biochemistry Research:
2-Bromoacetamide is also used as a precursor to dehydropeptidase I inactivator, an enzyme that is involved in the regulation of various biological processes. By inactivating this enzyme, researchers can study its function and its role in different diseases, which can lead to the development of new therapeutic strategies.

Hazard

A poison by ingestion. Moderately toxic by skin contact. A severe skin and eye irritant.

InChI:InChI=1/C2H4BrNO/c3-1-2(4)5/h1H2,(H2,4,5)

Upstream product

• 35070-76-9 N-chlorobromoacetamide 
• 110-83-8 cyclohexene 
• 7664-41-7 ammonia 

Downstream Products

• 871878-51-2 nitrilotri-acetic acid diamid-anilide 
• 50785-26-7 salicyloyloxy-acetic acid amide 
• 590-17-0 cyanomethyl bromide 
• 57837-02-2 2-(2,6-Diethyl-phenylamino)-acetamide 
• 35382-75-3 2-(6-chloro-2-oxo-4-phenyl-4H-benzo[d][1,3]oxazin-1-yl)-acetamide 
• 94360-69-7 2-[3-Cyano-4-(4-methoxy-phenyl)-6-phenyl-pyridin-2-ylsulfanyl]-acetamide 
• 94638-98-9 3-Amino-6-methyl-4-phenyl-thieno[2,3-b]pyridine-2-carboxylic acid amide 
• 94639-67-5 3-amino-4,6-diphenylthieno[2,3-b]pyridine-2-carboxamide 
• 94360-67-5 2-carbamoylmethylthio-4,6-diphenyl-3-cyanopyridine 
• 120385-97-9 3-((2-Carbamoylmethoxycarbonyl-ethylsulfanyl)-{3-[(E)-2-(7-chloro-quinolin-2-yl)-vinyl]-phenyl}-methylsulfanyl)-propionic acid carbamoylmethyl ester 
• 94360-68-6 2-[3-Cyano-6-(4-fluoro-phenyl)-4-phenyl-pyridin-2-ylsulfanyl]-acetamide 
• 108223-17-2 C₂₄H₁₉N₃OS 
• 85663-38-3 2-{4-[(1R,3S)-6-Fluoro-3-(4-fluoro-phenyl)-indan-1-yl]-piperazin-1-yl}-acetamide 
• 137296-22-1 2-[7-(4-Methoxy-benzyl)-2,6-dioxo-3-propyl-2,3,6,7-tetrahydro-purin-1-yl]-acetamide 

Relevant academic research and scientific papers

Inhibitors of sorotonin N-acetyltransferase

This invention is directed to a compound having the formula I. STR1 This invention is directed to a pharmaceutical composition comprising a compound which inhibits serotonin N-acetyltransferase having the formula I and a pharmaceutical acceptable carrier. The present invention relates to novel compounds and analogs which inhibit the serotonin N-acetyltransferase enzyme, and to processes for their preparation.

The photochemical addition of N-haloamides to olefins: the influence of various factors on the competition between 1,2-addition and hydrogen abstraction

In the photodecomposition of N-haloamides (ZCONRX) in the presence of olefins, the 1,2-addition chain competes with the hydrogen abstraction chain(s) leading to the parent amide (the quantum yields for these processes are greater than unity).The following factors were shown to have an influence on this competition as measured by the yield of 1,2-addition and the yield of parent amide in methylene chloride solutions: (i) the N-halogen (higher yields of addition with X=Cl than with X=Br); (ii) the electronegativity of Z (increase of the yield of addition as the electronegativity of Z increases); (iii) the temperature (higher yields of addition at lower temperatures, and at -70 degC, better yields of addition (>90percent, R=H) for X=Br than for X=Cl); and (iv) the size of R (dramatic decrease of the yield of 1,2-addition in going from R=H to R=CH3).Surprisingly, the presence of a scavenger for HX had no influence on the yield of 1,2-addition.Both the size and electronegativity of Z had an effect on the stereochemistry of 1,2-addition to cyclohexene.High yields of addition to a variety of olefins were obtained with N-chloroamides such as ClCH2CONHCl, C2H5OCONHCl, CF3CONHCl.Their addition to enol ethers at -70 degC led to the synthesis of α-amido acetals or ketals (aldehydes or ketones) and to an α-amido glycoside in good yields.