5-chloro-3-ethynylpyridin-2-amine

Base Information

• Chemical Name: 5-chloro-3-ethynylpyridin-2-amine
• CAS No.: 866318-88-9
• Molecular Formula: C7H5ClN2
• Molecular Weight: 152.583
• Hs Code.: 2933399990
• Mol file: 866318-88-9.mol

Synonyms:5-chloro-3-ethynylpyridin-2-amine;5-Chloro-3-ethynyl-2-aMinopyridine;2-Amino-5-chloro-3-ethynylpyridine

Chemical Property of 5-chloro-3-ethynylpyridin-2-amine

Chemical Property:

• Melting Point: 118～119℃
• PSA: 38.91000
• LogP: 1.87970
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-chloro-3-ethynylpyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-3-ethynylpyridin-2-amine

There total 1 articles about 5-chloro-3-ethynylpyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-bromo-5-chloropyridine (26163-03-1) → 5-chloro-3-ethynylpyridin-2-ylamine (866318-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine; copper(l) iodide / tetrahydrofuran / -5 - 5 °C / Inert atmosphere

2: potassium tert-butylate / ethanol / 20 - 30 °C

With copper(l) iodide; potassium tert-butylate; triethylamine; In tetrahydrofuran; ethanol;

Reference yield:

5-chloro-3-ethynylpyridin-2-ylamine (866318-88-9) → 5-chloro-1-(4-(4-(pyridin-2-yl)-1-(6-methylpyridin-3-yl)-1H-imidazol-2-yl)phenyl)-1H-pyrrolo[2,3-b]pyridine

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tetrachloroaurate dihydrate / ethanol / 34.5 h / 20 - 80 °C

2: potassium phosphate / trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide / 1,4-dioxane / 48 h / 110 °C

With potassium phosphate; sodium tetrachloroaurate dihydrate; trans-N,N'-dimethyl-1,2-cyclohexyldiamine; copper(l) iodide; In 1,4-dioxane; ethanol;

Reference yield:

5-chloro-3-ethynylpyridin-2-ylamine (866318-88-9) → 5-chloro-1H-pyrrolo[2,3-b]pyridine (866546-07-8)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 16 h / 20 - 30 °C

2: water / 0.5 h

In water; N,N-dimethyl-formamide;

upstream raw materials:

2-amino-3-bromo-5-chloropyridine

Downstream raw materials:

5-chloro-1H-pyrrolo[2,3-b]pyridine

Refernces