6,7-dihydro-5-methyl-2-(phenoxymethyl)-Thiazolo[5,4-c]pyridin-4(5H)-one

Base Information

Chemical Name:6,7-dihydro-5-methyl-2-(phenoxymethyl)-Thiazolo[5,4-c]pyridin-4(5H)-one
CAS No.:1312414-28-0
Molecular Formula:C₁₄H₁₄N₂O₂S
Molecular Weight:274.343
Hs Code.:

Synonyms:6,7-dihydro-5-methyl-2-(phenoxymethyl)-Thiazolo[5,4-c]pyridin-4(5H)-one

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Chemical Property of 6,7-dihydro-5-methyl-2-(phenoxymethyl)-Thiazolo[5,4-c]pyridin-4(5H)-one

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Technology Process of 6,7-dihydro-5-methyl-2-(phenoxymethyl)-Thiazolo[5,4-c]pyridin-4(5H)-one

There total 8 articles about 6,7-dihydro-5-methyl-2-(phenoxymethyl)-Thiazolo[5,4-c]pyridin-4(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1312415-07-8
2-hydroxymethyl-5-methyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

: 108-95-2,27073-41-2
phenol

: 1312414-28-0
5-methyl-2-phenoxymethyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Guidance literature:: With di-tert-butyl-diazodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Sealed tube; Inert atmosphere;

Reference yield:

: 1035219-96-5
2-bromo-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

: 1312414-28-0
5-methyl-2-phenoxymethyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 50 °C / 18751.9 Torr

2: caesium carbonate / N,N-dimethyl-formamide / 60 h / 20 °C / Inert atmosphere

3: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Sealed tube

4: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C / Sealed tube; Inert atmosphere

With methanol; sodium tetrahydroborate; di-tert-butyl-diazodicarboxylate; caesium carbonate; triethylamine; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; N,N-dimethyl-formamide;

Reference yield:

: 845267-78-9
tert-butyl 2,4-dioxopiperidine-1-carboxylate

: 1312414-28-0
5-methyl-2-phenoxymethyl-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 8 steps

1: N-Bromosuccinimide / tetrachloromethane / 2 h / 10 - 15 °C

2: sodium hydrogencarbonate / ethanol / 2.5 h / 80 °C

3: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

4: copper(ll) bromide; isopentyl nitrite / acetonitrile / 1.5 h / 20 °C

5: triethylamine / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / tetrahydrofuran / 50 °C / 18751.9 Torr

6: caesium carbonate / N,N-dimethyl-formamide / 60 h / 20 °C / Inert atmosphere

7: sodium tetrahydroborate; methanol / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere; Sealed tube

8: triphenylphosphine; di-tert-butyl-diazodicarboxylate / tetrahydrofuran / 2 h / 0 - 20 °C / Sealed tube; Inert atmosphere

With hydrogenchloride; methanol; sodium tetrahydroborate; N-Bromosuccinimide; di-tert-butyl-diazodicarboxylate; sodium hydrogencarbonate; caesium carbonate; triethylamine; triphenylphosphine; copper(ll) bromide; isopentyl nitrite; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; N,N-dimethyl-formamide; acetonitrile;